Toll-like receptor 9polymorphisms are associated with severity variables in a cohort of meningococcal meningitis survivors

Table 3 TLR9 + 2848 SNPs and severity variables in meningococcal meningitis patients ( p < 0.05)

Severity variable	TLR9 +2848 N (%)				P	OR	95% CI
	GG	GA	AA	Total
N. meningitidis in blood culture
Positive	42 (27)	80 (51)	36 (23)*	158	0.017	0.6	0.3 – 0.9
Negative	40 (22)	79 (43)	63 (35)*	182
Total	82	159	99	340
CSF leukocytes/μL
≤ 600	36 (27)	66 (50)	30 (23)*	132	0.028	1.7	1.1 – 2.9
> 600	50 (24)	91 (43)	72 (34)*	213
Total	86	157	102	345
≤ 1000	41 (25)	85 (53)	36 (22)**	162	0.005	2.0	1.2 – 3.2
> 1000	45 (25)	72 (39)	66 (36)**
Total	86	157	102

* = significance p < 0.05, ** = significance p < 0.01
Abbreviations: TLR: Toll-like receptor, OR: Odds ratio, 95% CI: 95% confidence interval, CSF: cerebrospinal fluid. Different numbers within groups are due to missing or non determined data in patient records.

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