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Table 2 TLR9 - 1237 SNPs and severity variables in meningococcal meningitis patients ( p < 0.05)

From: Toll-like receptor 9polymorphisms are associated with severity variables in a cohort of meningococcal meningitis survivors

Severity variable

TLR9 -1237 N (%)

   

P

OR

95% CI

 

TT

TC

CC

Total

   

N. meningitidis in blood culture

       

Positive

127 (80)

29 (18)*

3 (2)*

159

0.014

0.5

0.3 – 0.9

Not detected

124 (68)

52 (29)*

6 (3)*

182

   

Total

251

81

9

341

   

CSF leukocytes per μL

       

≤ 1000

129 (78)

34 (21)*

2 (1)*

165

0.029

1.7

1.1 – 2.8

> 1000

127 (68)

52 (29)*

6 (3)*

183

   

Total

253

87

8

348

   

CSF/blood glucose ratio

       

≤ 0.4

114 (69)

46 (28)*

6 (4)*

166

0.015

2.0

1.1 – 3.6

> 0.4

90 (82)

18 (16)*

2 (2)*

110

   

Total

204

64

8

276

   
  1. * = significance p < 0.05.
  2. Abbreviations: TLR: Toll-like receptor, OR: Odds ratio, 95% CI: 95% confidence interval, CSF: cerebrospinal fluid. Different numbers within groups are due to missing or non determined data in patient records.
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BMC Infectious Diseases

ISSN: 1471-2334

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