Figure 1

(A) Comparison of CSF leukocytes per μL in TLR9 - 1237 TC/CC carriers versus wild type (WT) carriers. Carriers of TLR9 -1237 TC/CC had significantly higher CSF leukocyte numbers compared to carriers of the TT WT (medians: 2117, interquartile range (IQR) 4987 versus 955, IQR 3938). Mann–Whitney U test, * p = 0.024. Abbreviatons: TLR: Toll-like receptor, SNP: single nucleotide polymorphism, CSF: cerebrospinal fluid, ul: microliter. (B) Comparison of CSF/blood glucose ratios in TLR9 -1237 TC/CC carriers versus WT carriers. Carriers of TLR9 -1237 TC/CC genotypes display significant lower ratios compared to carriers of the TT WT (medians: 0.20, IQR 0.4 versus 0.35, IQR 0.5). Mann–Whitney U test, * p = 0.017. Abbreviatons: TLR: Toll-like receptor, SNP: single nucleotide polymorphism, CSF: cerebrospinal fluid, ul: microliter. (C) Comparison of CSF leukocytes per μL in TLR9 +2848 AA mutant carriers versus GG/GA carriers. Carriers of the TLR9 AA mutant display significantly higher CSF leukocyte levels compared to GG/GA carriers (medians: 1907, IQR 5221 versus 891, IQR 3952). Mann–Whitney U test, ** p = 0.0067. Abbreviatons: TLR: Toll-like receptor, SNP: single nucleotide polymorphism, CSF: cerebrospinal fluid, ul: microliter.