Potential of novel Mycobacterium tuberculosis infection phase-dependent antigens in the diagnosis of TB disease in a high burden setting

Table 2 Abilities of resuscitation promoting factors (rpfs) to discriminate between TB disease and no TB.

Antigen	TB cases	HHCs	P-value	AUC	Cut-off	Sensitivity (%)	Specificity (%)
Rv0867c	0.0 (0.0-274.6)	52.2 (0.0-2173.3)	< 0.001	0.80	< 1.3	78 (18/23)	85 (17/20)
Rv2389c	0.0 (0.0-209.2)	25.8 (0.0-1056.0)	0.002	0.78	< 0.9	78 (18/23)	80 (16/20)
Rv2450c	0.0 (0.0-209.8)	29.2 (0.0-1123.5)	0.003	0.76	< 10.3	74 (17/23)	80 (16/20)
Rv1009	0.0 (0.0-184.2)	27.2 (0.0-1875.0)	0.001	0.79	< 0.3	78 (13/23)	80 (16/20)
Rv1884c	0.0 (0.0-158.3)	4.0 (0.0-481.1)	0.012	0.72	< 1.3	87 (20/23)	60 (12/20)

Median levels of IFN-γ (pg/ml) and ranges (in parenthesis) elicited upon stimulation of whole blood with rpfs and ability to discriminate between pulmonary TB (in 23 cases) and no TB disease (in 20 HHCs). AUC = Area under the ROC curve

ISSN: 1471-2334