Potential of novel Mycobacterium tuberculosis infection phase-dependent antigens in the diagnosis of TB disease in a high burden setting

Table 1 Abilities of DosR antigens to discriminate between TB disease and no TB.

Antigen	TB cases	HHCs	P-value	AUC	Cut-off value	Sensitivity (%)	Specificity (%)
Rv1735c	0.0 (0.0-140.9	12.0 (0.0-1049.0)	0.040	0.68	< 6	83 (19/23)	52 (11/21)
Rv2625c	0.0(0.0-1784.0)	17.3(0.0-1121.0)	0.007	0.74	< 6.1	83 (19/23)	70 (14/20)
Rv1996	0.0(0.0-180.6)	5.0(0.0- 314.1)	0.004	0.75	< 0.5	83 (19/23)	76 (16/21)
Rv2032	0.0(0.0-39.2)	17.7(0.0- 331.6)	0.002	0.77	< 0.1	83 (19/23)	70 (14/20)
Rv3126c	0.0(0.0-1173.0)	4.6(0.0- 820.6)	0.030	0.69	< 4.6	87 (20/23)	50 (10/20)
Rv0081	0.0(0.0-53.6)	5.5(0.0- 732.1)	0.020	0.71	< 9.4	96 (22/23)	50 (10/20)
Rv3130c	0.0(0.0-41.9)	0.0(0.0- 67.4)	0.050	68.0	< 1.1	91 (21/23)	45 (9/20)
Rv2624c	0.0(0.0-288.6)	3.4(0.0- 78.7)	0.010	0.73	< 1.0	91 (21/23)	55 (11/20)
Rv2028c	0.0(0.0-174.9)	0.0(0.0- 72.5)	0.030	0.69	< 2.3	96 (22/23)	45 (9/20)
Rv3134c	0.0(0.0-0.0)	0.0(0.0- 51.2)	0.050	0.68	< 4.9	100 (23/23)	35 (7/20)
Rv2006	0.0 (0.0-2738.0)	12.3 (0.0-1030.0)	0.002	0.77	< 1.0	83 (19/23)	80 (16/20)
Rv2629	0.0 (0.0-1720.0)	3.2 (0.0-331.6)	0.020	0.71	< 1.3	91 (21/23)	55 (11/20)
Rv2631	0.0 (0.0-1071)	0.0 (0.0-454.8)	0.030	0.69	< 1.3	96 (22/23)	45 (9/20)
Rv2007c	0.0 (0.0-3456.0)	0.7(0.0-447.9)	0.010	0.73	< 0.1	91 (21/23)	55 (11/20)

Median levels of IFN-γ (pg/ml) and ranges (in parenthesis) elicited in patients with active TB and household contacts by the most promising DosR antigens. Antigens that discriminated between the two groups with P-values < 0.05 are shown. Abilities of the antigens to differentiate between the two study groups are also shown. Antigens in bold discriminated between TB and no TB with AUC ≥ 0.70 after ROC analysis. AUC = Area under the ROC curve

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