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Table 1 Abilities of DosR antigens to discriminate between TB disease and no TB.

From: Potential of novel Mycobacterium tuberculosis infection phase-dependent antigens in the diagnosis of TB disease in a high burden setting

Antigen TB cases HHCs P-value AUC Cut-off
value
Sensitivity
(%)
Specificity
(%)
Rv1735c 0.0 (0.0-140.9 12.0 (0.0-1049.0) 0.040 0.68 < 6 83 (19/23) 52 (11/21)
Rv2625c 0.0(0.0-1784.0) 17.3(0.0-1121.0) 0.007 0.74 < 6.1 83 (19/23) 70 (14/20)
Rv1996 0.0(0.0-180.6) 5.0(0.0-
314.1)
0.004 0.75 < 0.5 83 (19/23) 76 (16/21)
Rv2032 0.0(0.0-39.2) 17.7(0.0-
331.6)
0.002 0.77 < 0.1 83 (19/23) 70 (14/20)
Rv3126c 0.0(0.0-1173.0) 4.6(0.0-
820.6)
0.030 0.69 < 4.6 87 (20/23) 50 (10/20)
Rv0081 0.0(0.0-53.6) 5.5(0.0-
732.1)
0.020 0.71 < 9.4 96 (22/23) 50 (10/20)
Rv3130c 0.0(0.0-41.9) 0.0(0.0-
67.4)
0.050 68.0 < 1.1 91 (21/23) 45 (9/20)
Rv2624c 0.0(0.0-288.6) 3.4(0.0-
78.7)
0.010 0.73 < 1.0 91 (21/23) 55 (11/20)
Rv2028c 0.0(0.0-174.9) 0.0(0.0-
72.5)
0.030 0.69 < 2.3 96 (22/23) 45 (9/20)
Rv3134c 0.0(0.0-0.0) 0.0(0.0-
51.2)
0.050 0.68 < 4.9 100 (23/23) 35 (7/20)
Rv2006 0.0 (0.0-2738.0) 12.3 (0.0-1030.0) 0.002 0.77 < 1.0 83 (19/23) 80 (16/20)
Rv2629 0.0 (0.0-1720.0) 3.2 (0.0-331.6) 0.020 0.71 < 1.3 91 (21/23) 55 (11/20)
Rv2631 0.0 (0.0-1071) 0.0 (0.0-454.8) 0.030 0.69 < 1.3 96 (22/23) 45 (9/20)
Rv2007c 0.0 (0.0-3456.0) 0.7(0.0-447.9) 0.010 0.73 < 0.1 91 (21/23) 55 (11/20)
  1. Median levels of IFN-γ (pg/ml) and ranges (in parenthesis) elicited in patients with active TB and household contacts by the most promising DosR antigens. Antigens that discriminated between the two groups with P-values < 0.05 are shown. Abilities of the antigens to differentiate between the two study groups are also shown. Antigens in bold discriminated between TB and no TB with AUC ≥ 0.70 after ROC analysis. AUC = Area under the ROC curve