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Table 3 Antibiotic Treatments and Clinical Outcomes in Patients with HCAP and CAPa

From: Healthcare-associated pneumonia among hospitalized patients in a Korean tertiary hospital

Treatment

HCAP

(n= 231)

CAP

(n= 296)

P-value

Inappropriate antibiotic therapy b

27/73 (37.0)

19/78 (24.4)

0.092

Monotherapy

30 (13.0)

53 (17.9)

0.124

   Amino-penicillins

3 (1.3)

5 (1.7)

-

   Cephalosporin

5 (2.2)

8 (2.7)

-

   Antipseudomonal penicillins

6 (2.6)

6 (2.0)

-

   Fluroquinolone

13 (5.6)

34 (11.5)

-

   Carbapenem

3 (1.3)

0 (0)

-

Combination therapy

201 (87.0)

243 (82.1)

0.124

   β-lactams + fluoroquinolone

4 (1.7)

8 (2.7)

-

   β-lactams + macrolide

36 (15.6)

112 (37.8)

<0.001

   β-lactams + clindamycin

10 (4.3)

14 (4.7)

-

   β-lactams + aminoglycoside

6 (2.6)

1 (0.3)

-

   Fluoroquinolone + clindamycin

13 (5.6)

12 (4.1)

-

   Antipseudomonal β-lactams + fluroquinolone

63 (27.3)

48 (16.2)

0.001

   Antipseudomonal β-lactams + macrolide

0 (0)

1 (0.3)

-

   Antipseudomonal β-lactams + clindamycin

6 (2.6)

3 (1.0)

-

   Antipseudomonal β-lactams + aminoglycoside

8 (3.5)

2 (0.7)

-

   Other combination therapyc

55 (23.8)

42 (14.2)

0.002

Clinical outcomes

   

   In-hospital mortality

65 (28.1)

32 (10.8)

<0.001

   Early treatment failured

56 (24.2)

37 (12.5)

<0.001

   ICU admission

49 (21.2)

37 (12.5)

0.007

   ICU mortality

31 (13.4)

21 (7.1)

0.016

   Need for mechanical ventilation

47 (20.3)

39 (13.2)

0.027

   Duration of hospital stay (days)

18.6 ± 19.1

12.9 ± 13.1

<0.001

  1. a Data are presented as numbers (percentages) unless otherwise indicated. Plus-minus values are means ± standard deviation.
  2. b Number of patients/total number of patients whose causative pathogens and antibiotic sensitivity test results are known (percentages). Results of antibiotics sensitivity test were not available in six patients with HCAP and five patients with CAP.
  3. c Others contain combination therapy of three or more drugs, including aminopenicillins, cephalosporin, antipseudomonal penicillin, aminglycoside, macrolide, clindamycin, fluoroquinolone, glycopeptide, trimethoprim/sulfamethoxazole, and antifungal agent.
  4. d Early treatment failure was defined as clinical deterioration within 72 h of treatment such as lack of response or worsening of fever, respiratory condition, and/or radiographic status requiring mechanical ventilation, aggressive fluid resuscitation or vasopressors, or death
  5. HCAP healthcare-associated pneumonia
  6. CAP community-acquired pneumonia
  7. ICU intensive care unit
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BMC Infectious Diseases

ISSN: 1471-2334

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