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Table 3 Antibiotic Treatments and Clinical Outcomes in Patients with HCAP and CAPa

From: Healthcare-associated pneumonia among hospitalized patients in a Korean tertiary hospital

Treatment HCAP
(n= 231)
CAP
(n= 296)
P-value
Inappropriate antibiotic therapy b 27/73 (37.0) 19/78 (24.4) 0.092
Monotherapy 30 (13.0) 53 (17.9) 0.124
   Amino-penicillins 3 (1.3) 5 (1.7) -
   Cephalosporin 5 (2.2) 8 (2.7) -
   Antipseudomonal penicillins 6 (2.6) 6 (2.0) -
   Fluroquinolone 13 (5.6) 34 (11.5) -
   Carbapenem 3 (1.3) 0 (0) -
Combination therapy 201 (87.0) 243 (82.1) 0.124
   β-lactams + fluoroquinolone 4 (1.7) 8 (2.7) -
   β-lactams + macrolide 36 (15.6) 112 (37.8) <0.001
   β-lactams + clindamycin 10 (4.3) 14 (4.7) -
   β-lactams + aminoglycoside 6 (2.6) 1 (0.3) -
   Fluoroquinolone + clindamycin 13 (5.6) 12 (4.1) -
   Antipseudomonal β-lactams + fluroquinolone 63 (27.3) 48 (16.2) 0.001
   Antipseudomonal β-lactams + macrolide 0 (0) 1 (0.3) -
   Antipseudomonal β-lactams + clindamycin 6 (2.6) 3 (1.0) -
   Antipseudomonal β-lactams + aminoglycoside 8 (3.5) 2 (0.7) -
   Other combination therapyc 55 (23.8) 42 (14.2) 0.002
Clinical outcomes    
   In-hospital mortality 65 (28.1) 32 (10.8) <0.001
   Early treatment failured 56 (24.2) 37 (12.5) <0.001
   ICU admission 49 (21.2) 37 (12.5) 0.007
   ICU mortality 31 (13.4) 21 (7.1) 0.016
   Need for mechanical ventilation 47 (20.3) 39 (13.2) 0.027
   Duration of hospital stay (days) 18.6 ± 19.1 12.9 ± 13.1 <0.001
  1. a Data are presented as numbers (percentages) unless otherwise indicated. Plus-minus values are means ± standard deviation.
  2. b Number of patients/total number of patients whose causative pathogens and antibiotic sensitivity test results are known (percentages). Results of antibiotics sensitivity test were not available in six patients with HCAP and five patients with CAP.
  3. c Others contain combination therapy of three or more drugs, including aminopenicillins, cephalosporin, antipseudomonal penicillin, aminglycoside, macrolide, clindamycin, fluoroquinolone, glycopeptide, trimethoprim/sulfamethoxazole, and antifungal agent.
  4. d Early treatment failure was defined as clinical deterioration within 72 h of treatment such as lack of response or worsening of fever, respiratory condition, and/or radiographic status requiring mechanical ventilation, aggressive fluid resuscitation or vasopressors, or death
  5. HCAP healthcare-associated pneumonia
  6. CAP community-acquired pneumonia
  7. ICU intensive care unit