5 years as compared to those ≤ 5 years are 0.370 (95% CI = 0.1733 - 0.7915, p = 0.010). In contrast, even when ParaCheck Pf® faint bands are considered positive, the odds of misdiagnosis by ParaCheck Pf® for those > 5 years as compared to those ≤ 5 years are 0.837 (95% CI = 0.459 - 1.547, p = 0.5383). Conclusions We provide compelling evidence that in areas of low transmission, "faint bands" should be considered a negative test when used to inform clinical decision-making. Correct interpretation of RDT test bands in a clinical setting plays a central role in successful malaria surveillance, appropriate patient management and most importantly reducing misdiagnosis."/>
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Table 2 The proportion of faint band appearance, ParaCheck Pf® misdiagnosis with either positive or negative "faint band" classification, local microscopy misdiagnosis and true positives.

From: Reducing malaria misdiagnosis: the importance of correctly interpreting Paracheck Pf®"faint test bands" in a low transmission area of Tanzania

ParaCheck® faint bands and misdiagnosis Proportion
ParaCheck Pf® tests resulting in a faint band (n = 291) 69 (23.7%)
ParaCheck Pf® positive (if classify faint as +) (n = 291) 74 (25.4%)
ParaCheck Pf® positive (if classify faint as -) (n = 291) 5 (1.7%)
ParaCheck Pf® Misdiagnosis (if classify faint as +) (n = 283) 68 (23.4%)
ParaCheck Pf® Misdiagnosis (if classify faint as -)
(n = 283)
1 (0.35%)
Misdiagnosis with local microscopy (n = 283) 131 (45.0%)
True positives determined by external QC (n = 283) 6 (2.1%)
ParaCheck Pf® faint Bands corresponding with true positives* (n = 69) 3 (4.3%)
ParaCheck Pf® faint Bands corresponding with true negatives* (n = 69) 65 (94.2%)
  1. *True positives and true negatives were determined by external quality control