Factors associated with paradoxical immune response to antiretroviral therapy in HIV infected patients: a case control study

Table 4 Logistic Regression Results.

Characteristics	Univariate analysis			Multivariate analysis^b
	p-value	OR	CI 95%	p-value	Aj OR	CI 95%
Total time in use of HAART	0.000^a	-	-	0.013^a	0.981	0.96-0.99
Concomitant medications over 30 consecutive days in previous year	0.002^a			0.109
Yes			-			-
No		0.29	0.13-0.65		0.423	0.14-1.21
Modifications in HAART before previous year due to abandonment or poor adherence	0.018^a			0.159
No			-			-
Yes		3.39	1.33-8.65		2.852	0.66-12.25
Regimen containing zidovudine	0.021^a			0.359
Yes			-			-
No		2.28	1.11-4.66		1.601	0.58-4.37
AIDS defining illness prior to HAART	0.040^a			0.515
Yes		0.88	0.28-2.77		1.475	0.45-4.74
No			-			-
Irregular use of HAART in previous year	0.071^a			0.403
Yes		2.22	0.91-5.39		1.888	0.42-8.36
No			-			-
Nadir CD4-count	0.000^a	-	-	0.000^a	0.985	0.97-0.99
Time of undetectable HIVVL	0.000^a	-	-	0.037^a	0.969	0.94-0.99

OR, odds ratio; CI 95%, confidence interval of 95%; Aj OR, adjusted odds ratio; HAART, highly active antiretroviral therapy; nadir CD4-count, the lowest CD4 ever presented by patient; HIVVL, HIV viral load; undetectable HIVVL, over time the most common limit of detection was less than 400 copies/ml.
^a p-value < 0,050.
^b Multivariate analysis was performed by the binary logistic regression model using Enter method for all variables with a p-value < 0.1 in the bivariate analysis model who fitted the requirements for logistic regression. It is important to note that the inclusion of variables in this model was performed according to a hierarchical causal theoretical tree previously developed for this study.

ISSN: 1471-2334