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Table 1 Summary of pharmacokinetic parameters for antimicrobials used in the Monte Carlo simulation

From: Pharmacodynamic evaluation of commonly prescribed oral antibiotics against respiratory bacterial pathogens

  Pharmacokinetic Parameter (mean ± SD)
Antibiotic CLT (L/hr) Vc (L) Fraction unbound (%)* Intercompartment Rate Constants (h-1) Absorption Rate Constant (h-1)
     K12 K21 K01
Amoxicillin ± clavulanate 22.2677 ± 5.8091 14.0622 ± 5.5932 80 ± 2 1.77 ± 2.27 1.91 ± 1.12 0.93 ± 0.49
Cefaclor 43.1513 ± 13.0045 29.3195 ± 8.3441 75 ± 5 0.45 ± 0.12 1.15 ± 0.35 2.61 ± 0.78
  CL_F (L/hr)      
Azithromycin 122 ± 33 --- ---    
Levofloxacin 10.5 ± 1.48 --- 62-76    
Gatifloxacin 12.54 ± 1.27 --- 78-82    
Moxifloxacin 14.9 ± 1.18 --- 49.5-70    
  1. * Fraction unbound estimates simulated as a mean (SD) Gaussian distribution for amoxicillin, co-amoxiclav, and cefaclor. Estimates simulated as a range for the FQ and azithromycin, where each value in the range has an equal likelihood of occurring.
  2. CLT = total body clearance reported from 2-compartment model; Vc = volume of the central compartment reported from 2-compartment model; K12 = intercompartment rate constant between first and second compartments; K21 = intercompartment rate constant between second and first compartments; K01 = absorption rate constant; CL_F = clearance accounting for bioavailability reported in pharmacokinetic analyses.