
Pharmacokinetic Parameter (mean ± SD)


Antibiotic

CLT (L/hr)

Vc (L)

Fraction unbound (%)*

Intercompartment Rate Constants (h^{1})

Absorption Rate Constant (h^{1})


   
K12

K21

K01


Amoxicillin ± clavulanate

22.2677 ± 5.8091

14.0622 ± 5.5932

80 ± 2

1.77 ± 2.27

1.91 ± 1.12

0.93 ± 0.49

Cefaclor

43.1513 ± 13.0045

29.3195 ± 8.3441

75 ± 5

0.45 ± 0.12

1.15 ± 0.35

2.61 ± 0.78


CL_F (L/hr)
     
Azithromycin

122 ± 33




   
Levofloxacin

10.5 ± 1.48



6276
   
Gatifloxacin

12.54 ± 1.27



7882
   
Moxifloxacin

14.9 ± 1.18



49.570
   
 * Fraction unbound estimates simulated as a mean (SD) Gaussian distribution for amoxicillin, coamoxiclav, and cefaclor. Estimates simulated as a range for the FQ and azithromycin, where each value in the range has an equal likelihood of occurring.
 CLT = total body clearance reported from 2compartment model; Vc = volume of the central compartment reported from 2compartment model; K12 = intercompartment rate constant between first and second compartments; K21 = intercompartment rate constant between second and first compartments; K01 = absorption rate constant; CL_F = clearance accounting for bioavailability reported in pharmacokinetic analyses.