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Table 2 Specificity of 24 Inno-Lia algorithms among 412 patients either HAART-naïve or exhibiting HIV-1 RNA ≥50 copies/mL despite HAART

From: High specificity of line-immunoassay based algorithms for recent HIV-1 infection independent of viral subtype and stage of disease

Alg # Definition N recent Specificity %
Single-band algorithms
2 if sgp120 ≤ 1
then RECENT
else older
16 96.1
3 if gp41 ≤.5
then RECENT
else older
0 100
3.1 if gp41 ≤ 1
then RECENT
else older
0 100
3.2 if gp41 ≤ 2
then RECENT
else older
6 98.5
4 if p31 = 0
then RECENT
else older
25 93.9
4.1 if p31 ≤ 0.5
then RECENT
else older
28 93.2
5 if p24 ≤ 0
then RECENT
else older
9 97.8
6 if p17 = 0
then RECENT
else older
33 92.0
Combined algorithms
7 if sgp120 + gp41 + p31 ≤ 4
then RECENT
else older
7 98.3
8 if gp41 ≤ 0.5
OR (sgp120 + gp41 + p31 ≤ 4)
OR (sgp120 + gp41 + p31 + p24 + p17≤ 6.5)
then RECENT
else older
13 96.8
8.1 if gp41 ≤ 0.5
OR (sgp120 + gp41 + p31 ≤ 4)
OR ((sgp120 + gp41 + p31 + p24 + p17≤ 6.5) AND p31≤1)
then RECENT
else older
13 96.8
9 if sgp120 + gp41 ≤ 4 AND p31 = 0
then RECENT
else older
7 98.3
10 if p31 = 0 AND p24 ≥ 2
then RECENT
else older
16 96.1
11 if (sgp120 + gp41 ≤ 2.5)
OR (sgp120 + gp41 + p31 + p24 + p17 ≤ 6.5)
OR (p31 = 0 AND p24 ≥ 2)
then RECENT
else older
23 94.4
11.1 if (sgp120 + gp41 ≤ 2.5)
OR ((sgp120 + gp41 + p31 + p24 + p17 ≤ 6.5) AND p31≤1)
OR (p31 = 0 AND p24 ≥ 2)
then RECENT
else older
23 94.4
12 if (p24 ≥ 2 AND p31 = 0)
OR (gp41 ≤.5)
OR (sgp120 + gp41 + p31 ≤ 4
OR sgp120 + gp41 + p31 + p24 + p17 ≤ 6.5)
then RECENT
else older
23 94.4
12.1 if (p24 ≥ 2 AND p31 = 0)
OR (gp41 ≤.5) OR (sgp120 + gp41 + p31 ≤ 4)
OR (p31 ≤ 1 AND (sgp120 + gp41 + p31 + p24 + p17 ≤ 6.5))
then RECENT
else older
23 94.4
13 if (sgp120 + gp41 ≤ 4 AND p31 = 0)
OR (p31 = 0 AND p24 ≥ 2)
then RECENT
else older
17 95.9
13.1 if gp41 ≤ 2
OR (p31 = 0 AND p24 ≥ 2)
then recent
else older
20 95.1
14 if (sgp120 + gp41 + p31 + p24 + p17 ≤ 6.5 AND p31 ≤ 1)
then RECENT
else older
8 98.1
15 if (sgp120 ≤ 1 AND p31 ≤ 1)
OR (gp41 ≤ 2 AND p31 ≤ 1)
OR (p17 ≥ 2 AND p31 = 0)
OR (p31 = 0 AND p24 ≥ 2)
then RECENT
else older
18 95.6
16 if (sgp120 ≤ 1 AND (p31 + p24 + p17 ≤ 2.5))
OR (gp41 ≤ 1 )
OR (p31 ≤ 0.5 AND (sgp120 + gp41+ p24 + p17 ≥ 15))
OR (p24 = 0 AND gp41 ≤ 2 )
OR (p24 ≥ 3 AND p31 = 0 )
then RECENT
else older
12 97.1
17 if (sgp120 * gp41) ≤ 2
then RECENT
else older
4 99.0
18 if (sgp120 * gp41 ≤ 1)
OR (p24 + p31 = 0)
then RECENT
else older
5 98.8