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Table 6 Sensitivity analysis

From: Impact of routine PCV7 (Prevenar) vaccination of infants on the clinical and economic burden of pneumococcal disease in Malaysia

Model parameters Range of values ICER (RM)
Dose regimen 3-4 doses 25,576 - 35,196
Herd effects   
Lower 95% bound on herd effects   
   Age 20-30 23% 37,648
   Age 40-64 1%  
   Age ≥ 65 11%  
Higher herd effects   
   Age 20-30 41% 31,886
   Age 40-64 20%  
   Age ≥ 65 31%  
Discounting of costs (benefits not discounted) 3% 33,140
Vaccine serotype coverage 61.7-71.7% 34,208 - 36,242
% cohort vaccinated 80-100% 31,711 - 32,751
Vaccine efficacy   
IPD 82.7% to 99.9% 34,377 - 40,896
Pneumonia -1.5% to 11% 34,802 - 35,788
Otitis Media 4.1% to 9.7% 35,184 - 35,209
Disease incidence   
Meningitis   26,703 - 41.777
Bacteraemia 50% to 200%
of base case
21,629 - 50,437
Pneumonia   34,723 - 35,433
Otitis Media   35,166 - 35,212