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Table 2 Number of paediatric middle ear fluid isolates (MEF), and among them, number of PCV-7 and 19A isolates, with per-group percentages of non-susceptibility to penicillin (PEN), amoxicillin (AMX), cefotaxime (CTX), and erythromycin (ERY)

From: Increase in serotype 19A prevalence and amoxicillin non-susceptibility among paediatric Streptococcus pneumoniae isolates from middle ear fluid in a passive laboratory-based surveillance in Spain, 1997-2009

  97-00 2001 2002 2003 2004 2005 2006 2007 2008 2009
MEF (n) 481 210 171 159 180 166 176 173 220 141
   PEN 69.0 58.1 58.5 42.8 36.7 45.8 41.5 47.4 53.2 51.1
   AMX - 8.1 8.8 8.2 6.7 6.0 10.8 19.0 25.0 24.1
   CTX 5.2 4.8 4.1 1.9 6.1 1.8 1.1 6.9 6.8 8.5
   ERY 55.3 51.0 51.5 45.3 42.8 48.8 49.4 48.6 52.7 44.7
PCV-7 (n) 340 132 109 77 64 40 33 23 22 15
   PEN 88.5 82.6 83.5 67.5 68.7 77.5 69.7 73.9 81.8 86.7
   AMX - 12.1 13.8 13.0 17.2 15.0 21.2 26.1 50.0 53.3
   CTX 6.5 7.6 6.4 3.9 12.5 2.5 3.0 8.7 9.1 6.7
   ERY 65.0 57.6 63.3 58.4 64.1 67.5 63.6 43.5 36.4 53.2
19A (n) 32 20 21 27 38 53 55 67 103 50
   PEN 50.0 40.0 23.8 44.4 47.4 62.3 67.3 70.1 80.6 84.0
   AMX - 0.0 0.0 7.4 2.6 5.7 21.8 38.8 37.9 38.0
   CTX 3.1 0.0 0.0 0.0 7.9 3.8 1.8 14.9 11.7 20.0
   ERY 50.0 65.0 33.3 59.3 68.4 79.2 78.2 82.1 85.4 76.0
  1. Non-susceptibility: PEN ≥ 0.12 μg/ml; AMX ≥ 4 μg/ml; CTX ≥ 2 μg/ml; ERY ≥ 0.5 μg/ml