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Table 2 Analysis of risk factors for community-associated C. difficile infection

From: Incidence of and risk factors for community-associated Clostridium difficile infection: A nested case-control study

Variable CA-CDI Cases (N = 304) Controls (N = 3040) Unadjusted OR (95% CI) Adjusted OR (95% CI)*
Age in Years (by category)     
   <18 years 45 (14.80) 814 (26.78) reference reference
   19 to 49 years 125 (41.12) 1296 (42.63) 0.94 (0.74, 1.19) 1.92 (1.32, 2.78)
   50 to 64 years 106 (34.87) 803 (26.41) 1.49 (1.16, 1.91) 2.36 (1.59, 3.49)
   65 to 74 years 18 (5.92) 92 (3.03) 2.03 (1.21, 3.43) 3.38 (1.73, 6.57)
   ≥75 years 10 (3.29) 35 (1.15) 2.90 (1.43, 5.90) 2.49 (1.01, 6.12)
Gender (female) 184 (60.53) 1570 (51.64) 1.44 (1.1, 1.83) 1.24 (0.95, 1.61)
History of Hospitalization in Previous Year 33 (10.86) 103 (3.39) 3.47 (2.30, 5.23) 1.60 (0.99, 2.60)
Charlson Comorbidity Index [Mean (SD)] 0.17 (0.62) 0.05 (0.27) 2.03 (1.55, 2.64) 1.33 (0.98, 1.79)
Inflammatory Bowel Disease 12 (3.95) 4 (0.13) 30.0 (9.68, 93.02) 41.89 (11.83, 148.35)
Antimicrobial Use     
   None 82 (26.97) 2120 (69.74) reference reference
   Any 222 (73.03) 920 (30.26) 6.12 (4.70, 7.98) 6.09 (4.59, 8.08)
Gastric Acid Suppressant Use     
   None 249 (81.91) 2883 (94.84) reference reference
   Any 55 (18.09) 157 (5.16) 4.07 (2.91, 5.69) 2.30 (1.56, 3.39)
  1. NOTE. Data are number (%) of patients, unless otherwise stated.
  2. * Adjusted for all other covariates
  3. Includes proton pump inhibitors and histamine-2 receptor antagonists.