Table 2 Analysis of risk factors for community-associated C. difficile infection
Variable | CA-CDI Cases (N = 304) | Controls (N = 3040) | Unadjusted OR (95% CI) | Adjusted OR (95% CI)* |
|---|---|---|---|---|
Age in Years (by category) | Â | Â | Â | Â |
   <18 years | 45 (14.80) | 814 (26.78) | reference | reference |
   19 to 49 years | 125 (41.12) | 1296 (42.63) | 0.94 (0.74, 1.19) | 1.92 (1.32, 2.78) |
   50 to 64 years | 106 (34.87) | 803 (26.41) | 1.49 (1.16, 1.91) | 2.36 (1.59, 3.49) |
   65 to 74 years | 18 (5.92) | 92 (3.03) | 2.03 (1.21, 3.43) | 3.38 (1.73, 6.57) |
   ≥75 years | 10 (3.29) | 35 (1.15) | 2.90 (1.43, 5.90) | 2.49 (1.01, 6.12) |
Gender (female) | 184 (60.53) | 1570 (51.64) | 1.44 (1.1, 1.83) | 1.24 (0.95, 1.61) |
History of Hospitalization in Previous Year | 33 (10.86) | 103 (3.39) | 3.47 (2.30, 5.23) | 1.60 (0.99, 2.60) |
Charlson Comorbidity Index [Mean (SD)] | 0.17 (0.62) | 0.05 (0.27) | 2.03 (1.55, 2.64) | 1.33 (0.98, 1.79) |
Inflammatory Bowel Disease | 12 (3.95) | 4 (0.13) | 30.0 (9.68, 93.02) | 41.89 (11.83, 148.35) |
Antimicrobial Use | Â | Â | Â | Â |
   None | 82 (26.97) | 2120 (69.74) | reference | reference |
   Any | 222 (73.03) | 920 (30.26) | 6.12 (4.70, 7.98) | 6.09 (4.59, 8.08) |
Gastric Acid Suppressant Use†|  |  |  |  |
   None | 249 (81.91) | 2883 (94.84) | reference | reference |
   Any | 55 (18.09) | 157 (5.16) | 4.07 (2.91, 5.69) | 2.30 (1.56, 3.39) |