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Table 1 Predictors of species 7 and 9-type specific incidenta HPV infectionsb

From: Incident cervical infections with high- and low-risk human papillomavirus (HPV) infections among mothers in the prospective Finnish Family HPV Study

Covariates

Incident Species 7 and 9 HPV Infections

 

Crude IRR

95% CI

P

@Adjusted IRR

95% CI

P

Age (at study entry; continuous var)

0.98

0.96-1.02

0.090

0.99

0.98-1.01

0.678

Mother seroconverted to HR-HPV

      

   No

Ref

     

   Yes

0.81

0.67-0.98

0.039

0.84

0.69-1.03

0.106

Mother seropositive to HR-HPV at baseline

      

   Yes

Ref

     

   No

1.10

0.85-1.42

0.463

   

Baseline oral HR-HPV DNA status

      

   HR-HPV-

Ref

     

   HR-HPV+

0.80

0.54-1.19

0.285

   

Baseline PAP smear

      

   ASCUS+

Ref

     

   Negative (WNL)

1.76

0.76-4.10

0.184

   

Marital Status at baseline

      

   Singe

Ref

     

   Married

1.19

0.77-1.81

0.419

   

   Living with partner

1.30

0.86-1.97

0.208

   

   Divorced

1.42

0.95-2.15

0.086

   

Employment status

      

   Employed

Ref

     

   Student

0.82

0.61-1.10

0.192

   

   Unemployed

0.90

0.75-1.07

0.257

   

Age at onset of sexual activity

      

   Below 13 years

Ref

     

   Above 13 years

1.15

1.05-1.27

0.003

1.05

0.93-1.17

0.394

No. of sexual partners until age of 20 yrs

      

   0-2 partners

Ref

     

   3-5 partners

0.89

0.76-1.05

0.201

   

   6-10 partners

1.05

0.92-1.19

0.410

   

   > 10 partners

0.73

0.46-1.18

0.206

   

Life-time number of sexual partners

      

   1-2 partners

Ref

     

   3-5 partners

1.12

1.02-1.24

0.015

1.12

1.02-1.23

0.011

   6-10 partners

0.83

0.61-1.13

0.246

0.85

0.62-1.16

0.311

   > 10 partners

0.81

0.63-1.04

0.105

0.81

0.63-1.04

0.104

No. of weekly intercourse

      

   0-1 intercourse

Ref

     

   2-4 intercourses

NC

     

   5-10 intercourses

NC

     

   > 10 intercourses

NC

     

   > 10 vs. 0-1 (only calculable)

1.03

0.88-1.14

0.961

   

No. of deliveries in all partnerships (continuous var)*

1.06

0.98-1.15

0.107

   

Practices of oral sex

      

   No

Ref

     

   Yes

1.02

0.87-1.20

0.739

   

Practices of anal sex

      

   No

Ref

     

   Yes

1.22

0.97-1.55

0.087

1.16

0.83-1.62

0.375

Initiation of OC usage

      

   Above 20 years

Ref

     

   Below 20 years

1.32

1.04-1.23

0.004

1.13

1.02-1.26

0.017

OC use (Y/N)

      

   Never use

Ref

     

   Ever use

1.01

0.74-1.37

0.948

   

Smoking habits

      

   Never smoker

Ref

     

   Ever smoker

1.06

0.92-1.21

0.384

   

Initiation of smoking

      

   10-13 years of age

      

   > 13 years of age

1.16

1.01-1.35

0.028

1.11

0.95-1.31

0.159

History of STD

      

   Yes

Ref

     

   No

1.06

0.89-1.27

0.505

   

History of genital warts

      

   No

Ref

     

   Yes

0.93

0.81-1.08

0.372

   

History of oral warts

      

   Yes

Ref

     

   No

1.08

0.79-1.32

0.823

   

2nd pregnancy during FU

      

   No 2nd pregnancy during FU

Ref

     

   Yes, 2nd pregnancy during FU

0.29

0.16-0.55

0.0001

0.32

0.17-0.61

0.0001

Change in marital status during FU*

      

   No

Ref

     

   Yes; living with partner

0.74

0.41-1.32

0.315

0.78

0.48-1.28

0.340

   Yes, married

1.04

0.89-1.22

0.572

1.10

0.84-1.45

0.474

   Yes, divorced

1.11

1.01-1.22

0.019

1.16

0.97-1.40

0.102

No. of current sexual partners*

      

   No

Ref

     

   1 or more

1.02

1.00-1.04

0.027

**

  
  1. Species 7 HPV genotypes: 18,39,45,59,68,70,85; Species 9 HPV genotypes: 16,31,33,35,52,58,67; aCount outcome (incident events/person time at risk), as defined by the first incident event in baseline HPV-negative women during the follow-up; bResults obtained from panel Poisson regression for count outcomes (log-link), clustered by woman-ID, FU visits as time variable, and 95%CI calculated by robust variance estimation; @adjusted for age and all significant univariates in the model; *the variables that are from the FU questionnaire; NC; no convergence obtained (with any working correlation structure) WNL, within normal limits; **rejected because of collinearity