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Table 1 Predictors of species 7 and 9-type specific incidenta HPV infectionsb

From: Incident cervical infections with high- and low-risk human papillomavirus (HPV) infections among mothers in the prospective Finnish Family HPV Study

Covariates Incident Species 7 and 9 HPV Infections
  Crude IRR 95% CI P @Adjusted IRR 95% CI P
Age (at study entry; continuous var) 0.98 0.96-1.02 0.090 0.99 0.98-1.01 0.678
Mother seroconverted to HR-HPV       
   No Ref      
   Yes 0.81 0.67-0.98 0.039 0.84 0.69-1.03 0.106
Mother seropositive to HR-HPV at baseline       
   Yes Ref      
   No 1.10 0.85-1.42 0.463    
Baseline oral HR-HPV DNA status       
   HR-HPV- Ref      
   HR-HPV+ 0.80 0.54-1.19 0.285    
Baseline PAP smear       
   ASCUS+ Ref      
   Negative (WNL) 1.76 0.76-4.10 0.184    
Marital Status at baseline       
   Singe Ref      
   Married 1.19 0.77-1.81 0.419    
   Living with partner 1.30 0.86-1.97 0.208    
   Divorced 1.42 0.95-2.15 0.086    
Employment status       
   Employed Ref      
   Student 0.82 0.61-1.10 0.192    
   Unemployed 0.90 0.75-1.07 0.257    
Age at onset of sexual activity       
   Below 13 years Ref      
   Above 13 years 1.15 1.05-1.27 0.003 1.05 0.93-1.17 0.394
No. of sexual partners until age of 20 yrs       
   0-2 partners Ref      
   3-5 partners 0.89 0.76-1.05 0.201    
   6-10 partners 1.05 0.92-1.19 0.410    
   > 10 partners 0.73 0.46-1.18 0.206    
Life-time number of sexual partners       
   1-2 partners Ref      
   3-5 partners 1.12 1.02-1.24 0.015 1.12 1.02-1.23 0.011
   6-10 partners 0.83 0.61-1.13 0.246 0.85 0.62-1.16 0.311
   > 10 partners 0.81 0.63-1.04 0.105 0.81 0.63-1.04 0.104
No. of weekly intercourse       
   0-1 intercourse Ref      
   2-4 intercourses NC      
   5-10 intercourses NC      
   > 10 intercourses NC      
   > 10 vs. 0-1 (only calculable) 1.03 0.88-1.14 0.961    
No. of deliveries in all partnerships (continuous var)* 1.06 0.98-1.15 0.107    
Practices of oral sex       
   No Ref      
   Yes 1.02 0.87-1.20 0.739    
Practices of anal sex       
   No Ref      
   Yes 1.22 0.97-1.55 0.087 1.16 0.83-1.62 0.375
Initiation of OC usage       
   Above 20 years Ref      
   Below 20 years 1.32 1.04-1.23 0.004 1.13 1.02-1.26 0.017
OC use (Y/N)       
   Never use Ref      
   Ever use 1.01 0.74-1.37 0.948    
Smoking habits       
   Never smoker Ref      
   Ever smoker 1.06 0.92-1.21 0.384    
Initiation of smoking       
   10-13 years of age       
   > 13 years of age 1.16 1.01-1.35 0.028 1.11 0.95-1.31 0.159
History of STD       
   Yes Ref      
   No 1.06 0.89-1.27 0.505    
History of genital warts       
   No Ref      
   Yes 0.93 0.81-1.08 0.372    
History of oral warts       
   Yes Ref      
   No 1.08 0.79-1.32 0.823    
2nd pregnancy during FU       
   No 2nd pregnancy during FU Ref      
   Yes, 2nd pregnancy during FU 0.29 0.16-0.55 0.0001 0.32 0.17-0.61 0.0001
Change in marital status during FU*       
   No Ref      
   Yes; living with partner 0.74 0.41-1.32 0.315 0.78 0.48-1.28 0.340
   Yes, married 1.04 0.89-1.22 0.572 1.10 0.84-1.45 0.474
   Yes, divorced 1.11 1.01-1.22 0.019 1.16 0.97-1.40 0.102
No. of current sexual partners*       
   No Ref      
   1 or more 1.02 1.00-1.04 0.027 **   
  1. Species 7 HPV genotypes: 18,39,45,59,68,70,85; Species 9 HPV genotypes: 16,31,33,35,52,58,67; aCount outcome (incident events/person time at risk), as defined by the first incident event in baseline HPV-negative women during the follow-up; bResults obtained from panel Poisson regression for count outcomes (log-link), clustered by woman-ID, FU visits as time variable, and 95%CI calculated by robust variance estimation; @adjusted for age and all significant univariates in the model; *the variables that are from the FU questionnaire; NC; no convergence obtained (with any working correlation structure) WNL, within normal limits; **rejected because of collinearity
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BMC Infectious Diseases

ISSN: 1471-2334

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