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Table 3 Serial response to the IP-10-based and IFN-γ-based assays in patients with active TB

From: IP-10 response to RD1 antigens might be a useful biomarker for monitoring tuberculosis therapy

 

QFT-IT antigens

 

RD1 selected peptides IFN-γ cut-off 0.57 IU/ml

 
 

Time points

 

Time points

 
 

T0

T6

p value

T0

T6

p value

IP-10

Positive over total (%)

16/17 (94.1)

14/17 (82.3)

0.6

16/17 (94.1)

7/17 (41.1)

0.002

IFN-γ

Positive over total (%)

17/17 (100)

14/17 (82.3)

0.2

16/17 (94.1)

7/17 (41.1)

0.002

IP-10

N of reversion over total (%)

-

3/17 (17.6)

 

-

10/17 (58.8)

 

IP-10 N of conversion over total (%)

-

1/17 (5.8)

 

-

0/17 (0)

 

IFN-γ

N of reversion over total (%)

-

3/17 (17.6)

 

-

9/17 (52.9)

 

IFN- γ

N of conversion over total (%)

-

0/17 (0)

 

-

0/17 (0)

 
  1. Footnotes: TB: tuberculosis; QFT-IT: QuantiFERON TB Gold In tube; IP: inducible protein; IFN: interferon; RD: region of difference; N: number; T0: baseline; T6: end of treatment.