Table 3 Summary of patient and treatment characteristics, and complications believed to be associated with antiviral resistance in the reviewed case reports
From: Systematic review of influenza resistance to the neuraminidase inhibitors
Study | Period | Flu type | Mutation | Proph/ Treat | Competent/ Compromised | In/Out Patient | Age | Days to resistance detection | Complications associated with resistance |
|---|---|---|---|---|---|---|---|---|---|
Oseltamivir resistance | |||||||||
Baz52 | 2005-2006 | H3N2 | E596G E119V I222V I223V | Treat | Compromised | In | 4 m | 14 | Respiratory complications, prolonged viral shedding (about 90 days) |
Baz52 | 2009 | H1N1 | H275Y | Postexp Proph | Competent | Out | 59y | 8 | None. Recovered after 2 weeks |
Campanini55 | 2009 | H3N2 | H274Y | Treat | Compromised | In | 2y | 18 | 42 days to resolution of flu symptoms |
Cane56 | 2010 | H1N1 | H275Y | Treat | Compromised | In | 3y | NA | 1 month to resolution of flu symptoms |
CDC-Weekly(1)57 | 2009 | H1N1 | H275Y I223V | Proph | Competent | Out | Teens | 27 | None ("uneventful recovery") |
CDC-Weekly(1)57 | 2009 | H1N1 | H275Y I223V | Proph | Competent | Out | Teens | 14 | None ("uneventful recovery") |
CDC-Weekly(2)48 | 2009 | H1N1 | H275Y | Treat | Compromised | In | Teens | 30 | 2 months to recovery |
CDC-Weekly(2)48 | 2009 | H1N1 | H275Y | Treat | Compromised | In | 40y | 30 | 2 months to revovery, prolonged neutron-penia and protracted bone marrow recovery, neutropenic fever, coagulase-negative Staphylococcus bacteremia, and Pneumocystis |
Couturier(1)59 | 2009 | H1N1 | H275Y | Treat | Compromised | In | 69y | 9 | Renal function declined. Died after 17 days. |
Couturier(2)59 | 2009 | H1N1 | H275Y | Treat | Compromised | In | 66y | 21 | Recovered after 1 month. Caught fever again after 3 months and died. |
Couturier(3)59 | 2009 | H1N1 | H275Y | Proph | Competent | Out | 36y | NA | None |
De Jong54 | 2005 | H5N1 | H274Y | Treat | Competent | In | 13y | 5 | Patient died. Suffered from hypoxia and pneumonia |
Dulek60 | 2009 | H1N1 | H275Y | Treat | Compromised | In | 18 m | 22 | 52 days of viral shedding, progressive pulmonary disease |
Gaur61 | 2009 | H1N1 | H275Y | Treat | Compromised | In | 10y | 14 | None reported |
Glikman62 | 2009 | H1N1 | H275Y | Treat | Compromised | In | 11y | 13 | Prolonged fever (> 21 days) |
Hill-Cawthorne63 | 2009 | H1N1 | H275Y | Treat | Compromised | Out | 56y | 20 | Prolonged fever and cough (2 months) |
Ison(1)64 | 2001 | NA | Asp198Asn Aer285Ala | Proph | Compromised | In | 2y | 42 | Continued rhinorrhea and dry cough, progressive respitatory distress, gastrointestinal bleeding. Eventually died. |
Ison(2)64 | 2002 | H3N2 | Arg142Gly Tyr195Phe | Treat | Compromised | In | 63y | 90 | Prolonged cough and nasal congestion |
Ison(3)64 | 2003 | H3N2 | Glu119Val Ser31Asn | Treat | Compromised | In | 60y | NA | Progressive respiratory compromise and pneumonia, continued respiratory failure. Died of haemorrhagic stroke. |
Le53 | 2005 | N5N1 | H274Y | Both | Competent | Out | 14y | 4 | None. Recovered after 2 weeks. |
Memoli65 | 2009 | H1N1 | Amino-acid position 245-248 | Treat | Compromised | In | 43y | 5 | None. Recovered after 2 weeks. |
Nguyen**66 | 2009 | H1N1 | H27Y | Treat | Compromised | In | 14y | 17 | Died of complications after 2 months |
| Â | Â | Â | I223R | Â | Â | Â | Â | Â | Â |
Rousset**67 | 2009 | H1N1 | H275Y | Treat | Compromised | In | 24y | 6 | Patient died at day 140 |
Speers68 | 2009 | H1N1 | H275Y | Treat | Compromised | In | 38y | 3 | None. Eventually died |
Thabet69 | 2009 | H1N1 | H274Y | Treat | Compromised | In | 3y | 10 | None reported. |
Van der Vries*70 | 2009 | H1N1 | H275Y | Treat | Compromised | In | 5y | 7 | Resolutions of symptoms after 3 months |
Zanamivir resistance | |||||||||
Gubareva16 | 1998 | NA | 152Argr-Lys | Treat | Compromised | In | 18 m | 8 | Not resolved, patients died. |
Van der Vries*70 | 2009 | H1N1 | I223R | Treat | Compromised | In | 5y | 56 | Resolutions of symptoms after 3 months |