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Table 2 Summary of symptoms and days to resolution of symptoms reported across association studies and incidence studies

From: Systematic review of influenza resistance to the neuraminidase inhibitors

Study Resistant patients Sensitive patients
  n Reported symptoms and durations n Reported symptoms and durations
Association studies     
Buchholz (2009) 48 11 Duration of sick leave:
Median: 7 days
IQR: 6 to 14
26 Duration of sick leave:
Median: 7 days
IQR: 7 to 10
Buchholz (2009) 48 38 Days confined to bed:
Median: 3.5 days
IQR: 2 to 7
93 Days confined to bed:
Median: 3 days
IQR: 2 to 5
Dharan (2009) 50 49 Activities limited: 1-7 days
Median: 4 days
97 Activities limited: 1-30 days
Median: 4 days
Dharan (2009) 50 38 Missed work or school: 1-10 days
Median: 4 days
97 Missed work or school: 1-30 days
Median: 4 days
Incidence studies     
Kiso (2004) 15 9 Duration of fever: 2-7 days
Median = 3 days
41 Duration of fever: 1-6 days
Median = 3 days
Hatakeyama (2007) 41 1 Duration of fever: 2 days 76 Mean duration of fever: 2.4 days
Stephenson (2009) 43 4 Duration of fever: 5-6 days
Full recovery after: 9-10 days
60 Authors commented no difference observed
     between resistant and sensitive patients