Table 2 Comparison between LC* and CC* in vitro antifungal susceptibilities of the most representative Candida species determined by Etest and Sensititre
Drug | Species (No of isolates) | Centre | Etest MIC mg/L | °Agreement % | Sensititre MIC mg/L | °Agreement % | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Â | Â | Â | Range | 50% | 90% | EA | CA | Range | 50% | 90% | EA | CA |
|  | All isolates (638) | LC | ≤0.002-1.5 | 0.19 | 0.5 | 93.1 | 99.4 | 0.015-2 | 0.5 | 1 | 89.9 | 98.6 |
| Â | Â | CC | 0.032-8 | 0.19 | 0.38 | Â | Â | 0.03-2 | 0.5 | 1 | Â | Â |
| Â | Candida albicans (327) | LC | 0.002-1 | 0.19 | 0.25 | 96.3 | 100 | 0.015-1 | 0.5 | 1 | 91.1 | 99.4 |
| Â | Â | CC | 0.032-1 | 0.19 | 0.25 | Â | Â | 0.06-1 | 0.5 | 0.5 | Â | Â |
| Â | Candida parapsilosis (144) | LC | 0.004-1.5 | 0.125 | 0.5 | 85.4 | 99.3 | 0.015-2 | 0.5 | 1 | 89.6 | 98.6 |
Amphotericin B | Â | CC | 0.032-0.75 | 0.19 | 0.25 | Â | Â | 0.03-1 | 0.5 | 0.5 | Â | Â |
| Â | Candida glabrata (77) | LC | 0.002-1.5 | 0.25 | 0.75 | 97.4 | 98.7 | 0.015-2 | 0.5 | 1 | 87 | 98.7 |
| Â | Â | CC | 0.047-1 | 0.25 | 0.5 | Â | Â | 0.06-1 | 0.5 | 1 | Â | Â |
| Â | Candida tropicalis (38) | LC | 0.032-1.5 | 0.25 | 0.5 | 86.8 | 97.4 | 0.06-2 | 0.5 | 2 | 97.7 | 89.5 |
| Â | Â | CC | 0.047-0.75 | 0.25 | 0.5 | Â | Â | 0.12-1 | 0.5 | 1 | Â | Â |
| Â | Candida krusei (15) | LC | 0.064-0.5 | 0.5 | 0.5 | 93.3 | 100 | 0.25-1 | 0.5 | 1 | 100 | 93.2 |
| Â | Â | CC | 0.25-1 | 0.5 | 1 | Â | Â | 0.5-2 | 1 | 1 | Â | Â |
|  | All isolates (638) | LC | ≤0.002-≥32 | 0.008 | 2 | 89.6 | 93 | ≤0.008-≥16 | 0.06 | 1 | 92.5 | 99.7 |
|  |  | CC | ≤0.002-≥32 | 0.008 | 1.5 |  |  | ≤0.008-≥16 | 0.06 | 1 |  |  |
|  | Candida albicans (327) | LC | ≤0.002-4 | 0.003 | 0.006 | 89.7 | 99 | ≤0.008-1 | 0.03 | 0.06 | 89.6 | 100 |
|  |  | CC | ≤0.002-3 | 0.003 | 0.006 |  |  | ≤0.008-2 | 0.03 | 0.06 |  |  |
Anidulafungin | Candida parapsilosis (144) | LC | 0.004-≥32 | 1.5 | 4 | 89.2 | 74.1 | 0.03-4 | 1 | 2 | 97.9 | 98.6 |
|  |  | CC | ≤0.002-≥32 | 1 | 2 |  |  | ≤0.008-2 | 1 | 2 |  |  |
|  | Candida glabrata (77) | LC | 0.003-2 | 0.012 | 0.032 | 92.0 | 100 | ≤0.008-2 | 0.03 | 0.12 | 94.8 | 100 |
|  |  | CC | 0.004-2 | 0.012 | 0.023 |  |  | ≤0.015-2 | 0.06 | 0.12 |  |  |
|  | Candida tropicalis (38) | LC | ≤0.002-0.064 | 0.016 | 0.032 | 84.2 | 100 | ≤0.008-1 | 0.06 | 0.25 | 89.5 | 100 |
| Â | Â | CC | 0.006-1.5 | 0.016 | 0.125 | Â | Â | 0.03-2 | 0.06 | 0.25 | Â | Â |
| Â | Candida krusei (15) | LC | 0.012-0.047 | 0.023 | 0.047 | 100 | 100 | 0.015-0.12 | 0.06 | 0.12 | 100 | 100 |
| Â | Â | CC | 0.012-0.047 | 0.023 | 0.047 | Â | Â | 0.06-0.12 | 0.06 | 0.12 | Â | Â |
|  | All isolates (638) | LC | ≤0.002-≥32 | 0.19 | 1 | 94.5 | 98.9 | ≤0.008-≥16 | 0.12 | 0.5 | 96.7 | 99.8 |
|  |  | CC | 0.012-≥32 | 0.19 | 0.75 |  |  | 0.015-≥16 | 0.12 | 0.5 |  |  |
|  | Candida albicans (327) | LC | ≤0.002-1 | 0.125 | 0.25 | 94.2 | 100 | 0.008-0.5 | 0.06 | 0.12 | 97.9 | 100 |
| Â | Â | CC | 0.012-1.5 | 0.094 | 0.19 | Â | Â | 0.015-1 | 0.06 | 0.12 | Â | Â |
| Â | Candida parapsilosis (144) | LC | 0.032-3 | 0.75 | 2 | 92.3 | 95.8 | 0.03-8 | 0.5 | 1 | 95.8 | 99.3 |
Caspofungin | Â | CC | 0.094-3 | 0.5 | 1 | Â | Â | 0.06-2 | 0.5 | 1 | Â | Â |
|  | Candida glabrata (77) | LC | 0.047-2 | 0.25 | 0.38 | 98.7 | 100 | 0.015-≥16 | 0.12 | 0.25 | 97.4 | 100 |
|  |  | CC | 0.125-1 | 0.19 | 0.25 |  |  | 0.03-≥16 | 0.12 | 0.25 |  |  |
| Â | Candida tropicalis (38) | LC | 0.016-0.38 | 0.19 | 0.25 | 94.7 | 100 | 0.03-0.5 | 0.06 | 0.25 | 92.1 | 100 |
| Â | Â | CC | 0.064-2 | 0.19 | 0.5 | Â | Â | 0.03-0.5 | 0.06 | 0.25 | Â | Â |
| Â | Candida krusei (15) | LC | 0.38-1 | 0.75 | 1 | 100 | 100 | 0.12-1 | 0.5 | 0.5 | 100 | 100 |
| Â | Â | CC | 0.38-1.5 | 0.5 | 1 | Â | Â | 0.12-0.5 | 0.5 | 0.5 | Â | Â |
|  | All isolates (638) | LC | 0.023-≥256 | 0.38 | 12 | 92.2 | 93.2 | ≤0.12-≥256 | 0.5 | 16 | 94.3 | 92.8 |
|  |  | CC | 0.032-≥256 | 0.38 | 8 |  |  | ≤0.12-≥256 | 0.5 | 16 |  |  |
|  | Candida albicans (327) | LC | 0.023-≥256 | 0.25 | 0.75 | 92.0 | 99.1 | ≤0.12-≥256 | 0.25 | 0.5 | 94.8 | 99.1 |
|  |  | CC | 0.047-32 | 0.25 | 0.75 |  |  | ≤0.12-32 | 0.25 | 0.5 |  |  |
|  | Candida parapsilosis (144) | LC | 0.32-≥256 | 0.5 | 2 | 95.8 | 97.2 | ≤0.12-128 | 1 | 4 | 97.2 | 96.7 |
Fluconazole |  | CC | 0.125-32 | 0.5 | 1.5 |  |  | ≤0.12-64 | 1 | 4 |  |  |
|  | Candida glabrata (77) | LC | 0.38-≥256 | 12 | ≥256 | 84.4 | 64.9 | 0.5-≥256 | 16 | 64 | 90.9 | 58.4 |
|  |  | CC | 0.125-≥256 | 8 | 48 |  |  | 0.5-≥256 | 16 | 64 |  |  |
|  | Candida tropicalis (38) | LC | 0.125-16 | 0.5 | 2 | 92.1 | 100 | 0.25-≥256 | 1 | 4 | 84.2 | 92.1 |
| Â | Â | CC | 0.032-32 | 0.5 | 2 | Â | Â | 0.25-16 | 1 | 4 | Â | Â |
|  | Candida krusei (15) | LC | 12-≥256 | 48 | ≥256 | 86.7 | 46.7 | 8-64 | 32 | 64 | 100 | 86.7 |
| Â | Â | CC | 16-128 | 32 | 64 | Â | Â | 32-64 | 32 | 64 | Â | Â |
|  | All isolates (638) | LC | ≤0.002-≥32 | 0.064 | 1 | 81.3 | 79.4 | ≤0.008-≥16 | 0.06 | 0.5 | 92.5 | 84.4 |
|  |  | CC | 0.004-≥32 | 0.064 | 1.5 |  |  | ≤0.008-≥16 | 0.06 | 0.5 |  |  |
|  | Candida albicans (327) | LC | 0.002-≥32 | 0.047 | 0.25 | 84.1 | 80.4 | ≤0.008-≥16 | 0.03 | 0.12 | 92.7 | 94.1 |
|  |  | CC | 0.004-1 | 0.064 | 0.25 |  |  | ≤0.008-0.25 | 0.06 | 0.12 |  |  |
|  | Candida parapsilosis (144) | LC | ≤0.002-1 | 0.032 | 0.25 | 87.5 | 84.7 | ≤0.008-0.5 | 0.12 | 0.12 | 94.4 | 82.7 |
Itraconazole |  | CC | 0.008-3 | 0.032 | 0.38 |  |  | ≤0.008-1 | 0.12 | 0.25 |  |  |
|  | Candida glabrata (77) | LC | ≤0.002-≥32 | 1.5 | ≥32 | 61.8 | 80.3 | 0.03-≥16 | 0.5 | ≥16 | 89.6 | 66.2 |
|  |  | CC | 0.004-≥32 | 2 | ≥32 |  |  | 0.06-≥16 | 0.5 | 2 |  |  |
|  | Candida tropicalis (38) | LC | 0.012-16 | 0.094 | 0.38 | 68.4 | 55.3 | 0.03-≥16 | 0.12 | 0.5 | 86.8 | 36.8 |
| Â | Â | CC | 0.016-3 | 0.125 | 1 | Â | Â | 0.06-1 | 0.25 | 0.5 | Â | Â |
| Â | Candida krusei (15) | LC | 0.125-32 | 1 | 2 | 86.7 | 73.3 | 0.12-0.5 | 0.25 | 0.5 | 100 | 73.3 |
| Â | Â | CC | 0.5-2 | 1 | 2 | Â | Â | 0.12-0.5 | 0.25 | 0.5 | Â | Â |
|  | All isolates (638) | LC | ≤0.002-≥32 | 0.064 | 0.5 | 92.8 | 94.2 | ≤0.008-≥8 | 0.03 | 0.5 | 91.8 | 96.1 |
|  |  | CC | 0.003-≥32 | 0.064 | 0.5 |  |  | ≤0.008-≥8 | 0.03 | 1 |  |  |
|  | Candida albicans (327) | LC | ≤0.002-≥32 | 0.047 | 0.094 | 95.7 | 99.7 | ≤0.008-≥8 | 0.015 | 0.03 | 90.8 | 98.8 |
|  |  | CC | 0.003-0.25 | 0.047 | 0.094 |  |  | ≤0.008-0.5 | 0.015 | 0.03 |  |  |
|  | Candida parapsilosis (144) | LC | 0.003-0.25 | 0.064 | 0.125 | 98.6 | 99.3 | ≤0.008-4 | 0.03 | 0.12 | 95.1 | 99.3 |
Posaconazole |  | CC | 0.012-4 | 0.047 | 0.125 |  |  | ≤0.008-1 | 0.06 | 0.12 |  |  |
|  | Candida glabrata (77) | LC | 0.003-≥32 | 1 | ≥32 | 66.2 | 57.1 | ≤0.008-≥8 | 0.5 | ≥8 | 90.9 | 77.9 |
|  |  | CC | 0.012-≥32 | 1 | 24 |  |  | 0.015-≥8 | 1 | ≥8 |  |  |
|  | Candida tropicalis (38) | LC | 0.016-1.5 | 0.094 | 0.19 | 94.7 | 97.4 | 0.015-≥8 | 0.12 | 1 | 84.2 | 92.1 |
| Â | Â | CC | 0.016-2 | 0.094 | 0.25 | Â | Â | 0.015-1 | 0.12 | 1 | Â | Â |
| Â | Candida krusei (15) | LC | 0.094-1 | 0.25 | 0.5 | 93.3 | 100 | 0.12-0.5 | 0.25 | 0.5 | 100 | 100 |
| Â | Â | CC | 0.19-0.5 | 0.25 | 0.5 | Â | Â | 0.12-0.5 | 0.25 | 0.5 | Â | Â |
|  | All isolates (638) | LC | ≤0.002-≥32 | 0.016 | 0.25 | 90.3 | 98.9 | ≤0.008-≥16 | 0.008 | 0.25 | 91.5 | 99.0 |
|  |  | CC | ≤0.002-≥32 | 0.023 | 0.25 |  |  | ≤0.008-8 | 0.008 | 0.25 |  |  |
|  | Candida albicans (327) | LC | ≤0.002-≥32 | 0.012 | 0.032 | 86.2 | 99.4 | ≤0.008-≥16 | ≤0.008 | 0.015 | 92.7 | 99.4 |
|  |  | CC | ≤0.002-0.25 | 0.016 | 0.047 |  |  | ≤0.008-0.25 | ≤0.008 | ≤0.008 |  |  |
|  | Candida parapsilosis (144) | LC | ≤0.002-1 | 0.016 | 0.094 | 91.7 | 100 | ≤0.008-1 | 0.015 | 0.12 | 90.3 | 100 |
Voriconazole |  | CC | ≤0.002-1 | 0.016 | 0.094 |  |  | ≤0.008-1 | 0.015 | 0.06 |  |  |
|  | Candida glabrata (77) | LC | 0.004-≥32 | 0.25 | 1.5 | 85.7 | 94.8 | ≤0.008-≥16 | 0.25 | 1 | 89.6 | 89.6 |
|  |  | CC | 0.006-≥32 | 0.25 | 1.5 |  |  | ≤0.008-8 | 0.25 | 1 |  |  |
|  | Candida tropicalis (38) | LC | 0.016-0.5 | 0.047 | 0.125 | 86.8 | 100 | ≤0.008-16 | 0.06 | 1 | 86.8 | 94.7 |
| Â | Â | CC | 0.012-1 | 0.064 | 0.25 | Â | Â | 0.015-1 | 0.06 | 0.25 | Â | Â |
| Â | Candida krusei (15) | LC | 0.094-0.75 | 0.25 | 0.5 | 100 | 100 | 0.06-0.5 | 0.25 | 0.5 | 100 | 100 |
| Â | Â | CC | 0.19-0.75 | 0.38 | 0.5 | Â | Â | 0.12-0.5 | 0.25 | 0.5 | Â | Â |