Dosage effect on uropathogenic Escherichia coli anti-adhesion activity in urine following consumption of cranberry powder standardized for proanthocyanidin content: a multicentric randomized double blind study

Howell, Amy B; Botto, Henry; Combescure, Christophe; Blanc-Potard, Anne-Béatrice; Gausa, Lluis; Matsumoto, Tetsuro; Tenke, Peter; Sotto, Albert; Lavigne, Jean-Philippe

doi:10.1186/1471-2334-10-94

Table 1 Urinary bacterial Anti-Adhesion Activity (AAA) detected with Mannose-resistant Hemagglutination (MRHA) assay (A) and urinary bacterial adhesion to T24 cells (B) expressed as Adhesion Index (AI) following consumption of increasing doses of cranberry powder standardized for 18, 36 or 72 mg of proanthocyanidins (PAC) vs placebo by participants in the 4 countries.

From: Dosage effect on uropathogenic Escherichia coli anti-adhesion activity in urine following consumption of cranberry powder standardized for proanthocyanidin content: a multicentric randomized double blind study

A	AAA				P
Regimen	Placebo	18 mg PAC	36 mg PAC	72 mg PAC	18 vs 36	36 vs 72	6 h vs 24 h	Sp-Fr vs Ja-Hu
Spain (n = 8)
0 h	0% [0-0]	0% [0-0]	0% [0-0]	ND
1-6 h	0% [0-0]	50% [50-100]	100% [50-100]	ND	0.002	ND	<0.001	<0.001
24 h	0% [0-0]	0% [0-0]	12.5% [0-50]	ND	0.01	ND	<0.001
France (n = 8)
0 h	0% [0-0]	0% [0-0]	0% [0-0]	ND
1-6 h	0% [0-0]	50% [50-100]	75% [50-100]	ND	0.005	ND	<0.001
24 h	0% [0-0]	0% [0-0]	0% [0-0]	ND	NS	ND	<0.001
Japan (n = 8)								<0.001
0 h	12.5% [0-50]	ND	25% [0-50]	25% [0-50]
1-6 h	0% [0-0]	ND	100% [100-100]	100% [100-100]	ND	NS	<0.001
24 h	0% [0-0]	ND	12.5% [0-50]	75% [50-100]	ND	0.001	0.005
Hungary (n = 8)
0 h	0% [0-0]	ND	0% [0-0]	0% [0-0]
1-6 h	0% [0-0]	ND	87.5% [50-100]	100% [100-100]	ND	NS	<0.001
24 h	0% [0-0]	ND	25% [0-50]	25% [0-50]	ND	NS	<0.001
Total (n = 32)
0 h	0.3% [0-0]	0% [0-0]	0.6% [0-50]	12.5% [0-50]
1-6 h	0% [0-0]	50% [50-100]	90.6% [50-100]	100% [100-100]	0.003	NS	<0.001	ND
24 h	0% [0-0]	0% [0-0]	12.5% [0-50]	50% [50-100]	0.01	<0.001	<0.001	ND
B	AI Median [Range]				P
Regimen	Placebo	18 mg PAC	36 mg PAC	72 mg PAC	18 vs 36	36 vs 72	6 h vs 24 h	Sp-Fr vs Ja-Hu
Spain (n = 8)
1-6 h	18.5 [15-22]	8.5 [5-14]	5.0 [1-11]	-	<0.001	ND	<0.001	<0.001
24 h	20.0 [18-22]	14.5 [10-18]	12.5 [5-17]	-	<0.001	ND	<0.001
France (n = 8)
1-6 h	17.5 [15-28]	8.0 [5-16]	4.0 [2-10]	-	<0.001	ND	<0.001
24 h	19.5 [18-25]	17.5 [12-22]	5.0 [2-10]	-	<0.001	ND	<0.001
Japan (n = 8)								<0.001
1-6 h	21.5 [18-28]	-	5.0 [1-9]	3.5 [1-6]	ND	NS	<0.001
24 h	25.5 [17-29]	-	13.5 [10-18]	10.0 [2-15]	ND	0.01	<0.001
Hungary (n = 8)
1-6 h	18.5 [15-22]	-	2.0 [1-5]	1.0 [1-5]	ND	NS	<0.001
24 h	20 [15-25]	-	9.5 [5-25]	4.5 [2-10]	ND	<0.001	<0.001
Total (n = 32)
1-6 h	21.5 [15-28]	10.5 [5-16]	5.9 [1-11]	2.5 [1-6]	<0.001	<0.001	<0.001	ND
24 h	22.3 [15-29]	16.0 [10-22]	14.5 [2-25]	9.9 [2-15]	<0.001	<0.001	<0.001	ND

The results are representative of at least three independent trials. NS, not significant; ND, not determined. 0 h, pre-cranberry consumption collection

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ISSN: 1471-2334

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