Table 3 Summary of results targeting MTC polymorphic loci
From: Distinct genotypic profiles of the two major clades of Mycobacterium africanum
Target Locus | Node #(s) in Fig. 2 | M. tuberculosis(n) | M. africanumWA-1 (n) | M. africanumWA-2 (n) | Other MTC (n) |
|---|---|---|---|---|---|
RD loci | Â | Â | Â | Â | Â |
RD12can/RD12 1 | 1, 17 | intact (18) | intact (20) | intact (9) | Â |
3'cfp32 | 1 | intact (18) | intact (20) | intact (9) | Â |
TbD1 | 2 | deleted (18) | intact (20) | intact (9) | Â |
pks15/1 | 3, 9 | 7-bp deletion (18) | intact (20) | 6-bp deletion (9) | Â |
PPE55 2 | 4, 16 | intact (9) fail (9) | intact (20) | intact (9) | Â |
MiD3/RDRio 2 (IS1561' + PPE55) | 4, 16 | intact (9) fail (9) | intact (20) | intact (9) | Â |
RD9 | 6 | intact (18) | deleted (20) | deleted (9) | Â |
RD713 3 | 7 | fail (18) | deleted (20) | fail (9) | Â |
RD711 | 8 | intact (18) | deleted (20) | intact (9) | Â |
RD7 3 | 9 | intact (18) | intact (20) | deleted (9) | Â |
RD8 | 9 | intact (18) | intact (20) | deleted (9) | Â |
RD10 | 9 | intact (18) | intact (20) | deleted (9) | Â |
RD701 | 11 | intact (18) | intact (20) | deleted (9) | Â |
RD702 | 11 | intact (18) | intact (20) | deleted (9) | Â |
RD1das/RD1bcg 4 | 14, 19 | intact (18) | intact (20) | intact (9) | Â |
RD13 | 17 | intact (18) | intact (20) | intact (9) | Â |
RD4 | 18 | intact (18) | intact (20) | intact (9) | Â |
SNP loci | Â | Â | Â | Â | Â |
narGHJI -215 | 2 | C→T (18) | no Δ (20) | no Δ (9) |  |
katG 463 | 3 | CTG→CGG (18) | no Δ (20) | no Δ (9) |  |
gyrA 95 | 5 | no Δ (18) | no Δ (20) | no Δ (9) |  |
gyrB 1450 | 6 | no Δ (18) | G→T (20) | G→T (9) |  |
TbD1197 | 7 | fail (18) | C→T (20) | no Δ (9) |  |
aroA 285 | 7 | no Δ (18) | G→A (20) | no Δ (9) |  |
Rv1332 523 | 7 | no Δ (27) | G→T (32) | no Δ (11) | no Δ (15) |
katG 203 | 9 | no Δ (18) | no Δ (20) | ACC→ACT (9) |  |
3'cfp32 311 | 9 | no Δ (18) | no Δ (20) | G→A (9) |  |
RD13174 | 9 | no Δ (18) | no Δ (20) | G→A (9) |  |
PPE55 2148 | 9 | no Δ (9) fail (9) | no Δ (20) | A→G (9) |  |
PPE55 2154 | 9 | no Δ (9) fail (9) | no Δ (20) | A→G (9) |  |
Rv1510 1129 | 10 | no Δ (18) | no Δ (20) | G→A (9) |  |
hsp65 540 | 11 | no Δ (18) | no Δ (20) | C→G (9) |  |
nat 751 | 11 | no Δ (63) | no Δ (32) | G→A (27) | no Δ (53) |
rpoB 1163 | 12 | no Δ (18) | no Δ (20) | C→T (9) |  |
rpoB 1049 | 13 | no Δ (18) | no Δ (20) | no Δ (9) |  |
mmpL6 551 | 15 | fail (18) | no Δ (20) | no Δ (9) |  |
Other targets | Â | Â | Â | Â | Â |
cfp32 | Â | intact (18) | intact (20) | intact (9) | Â |