Trends in CD4 counts in HIV-infected patients with HIV viral load monitoring while on combination antiretroviral treatment: results from The TREAT Asia HIV Observational Database

Table 4 Sensitivity analyses of the CD4 count slope.

	Final model		Initial treatment, before any class change or stop for more than 30 days		Initial NNRTI-based regimen, before change or stop for more than 30 days		Including patients with 4 or more CD4 slopes endpoints
	Difference*	(95% CI)	Difference*	(95% CI)	Difference*	(95% CI)	Difference*	(95% CI)
		Observations = 10899		Observations = 6697		Observations = 4058		Observations = 9826
		Patients = 1676		Patients = 1353		Patients = 863		Patients = 1079
Current age, per 10 yrs older
per unit	-4.8	(-8.6, -1.0)	-4.0	(-9.0, 1.0)	-2.4	(-9.2, 4.4)	-4.3	(-8.4, -0.2)
Concurrent viral load, per log10 copies per mL higher
per unit	-40.5	(-48.4, -32.6)	-43.4	(-58.5, -28.4)	-45.1	(-68.0, -22.2)	-39.5	(-48.1, -30.9)
Concurrent CD4 per 100 per μL higher
per unit	1.9	(0.2, 3.7)	3.4	(1.0, 5.7)	4.1	(0.9, 7.3)	1.9	(0.0, 3.8)
Disease stage
CDC Category A*	0.0		0.0		0.0		0.0
TB and/or other ADI	26.3	(15.6, 37.0)	29.9	(16.1, 43.7)	29.9	(13.9, 45.9)	26.4	(14.6, 38.1)
Non-TB ADI(s)	12.0	(2.5, 21.4)	16.4	(3.4, 29.4)	16.3	(-1.2, 33.9)	11.2	(0.9, 21.6)
Hepatitis B or C coinfection
No*	0.0		0.0		0.0		0.0
Yes	-17.7	(-29.7, -5.7)	-17.5	(-33.1, -2.0)	-19.8	(-39.6, 0.0)	-18.7	(-31.9, -5.5)
Time since ART initiation
> 6 to ≤ 12 months*	0.0		0.0		0.0		0.0
> 12 to ≤ 18 months	-21.5	(-37.8, -5.2)	-29.4	(-48.2, -10.6)	-16.3	(-40.9, 8.3)	-19.6	(-37.8, -1.4)
> 18 to ≤ 24 months	-25.8	(-42.0, -9.7)	-32.8	(-51.9, -13.7)	-13.9	(-38.8, 10.9)	-25.8	(-43.6, -7.9)
> 24 or more months	-59.1	(-71.7, -46.5)	-65.6	(-80.7, -50.5)	-55.4	(-75.3, -35.5)	-59.1	(-73.1, -45.0)
Constant	205.5	(174.4, 236.6)	207.2	(157.7, 256.6)	192.8	(121.4, 264.2)	200.6	(166.6, 234.6)

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