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Table 4 Results of neutralization test with poliovirus type 1 strain CHAT and Poliovirus Type 1 Strain Sabin (LSc-2ab) in three different laboratories.

From: Immunity status of adults and children against poliomyelitis virus type 1 strains CHAT and Sabin (LSc-2ab) in Germany

 

Laboratory Nr. 1

Laboratory Nr. 2

Laboratory Nr. 3

Case

No.

CHAT

ATTC

VR-1562

Sabin 1

WHO reference strain

Ratio*

CHAT

ATTC

VR-1562

Sabin 1

WHO reference strain

Ratio

CHAT

ATTC

VR-1562

Sabin 1

WHO reference strain

Ratio

 

GMT** (IU/ml)

GMT (IU/ml)

 

GMT IU/ml

GMT IU/ml

 

GMT IU/ml

GMT IU/ml

 

7b

< 8 (< 1,1)

91 (4,9)

> 4,5

12 (0,6)

192 (4,1)

7,1

< 10 (< 1,3)

80 (5,3)

> 4,1

9

8 (1,1)

64 (3,4)

3,1

32 (1,5)

128 (2,7)

1,8

< 10 (< 1,3)

40 (2,7)

> 2,0

12b

23 (3,2)

362 (19,5)

6,1

64 (3,1)

256 (5,5)

1,8

10 (2,6)

160 (10,6)

4,1

13b

32 (4,4)

> 786 (> 42,3)

> 9,4

48 (2,3)

> 512 (> 11)

> 4,7

20 (5,2)

640 (42,4)

8,2

28b

32 (4,4)

64 (3,4)

0,8

96 (4,6)

128 (2,7)

0,6

20 (5,2)

40 (2,7)

0,5

16b

64 (8,9)

512 (27,5)

3,1

128 (6,2)

512 (11,0)

1,8

20 (5,2)

320 (21,2)

4,1

21

128 17,8

2048 110,1

6,2

384 (18,6)

> 512 (> 11)

> 0,6

40 (10,4)

1280 (84,8)

8,2

8b

256 (35,6)

362 (19,5)

0,5

512 (24,8)

512 (11,0)

0,4

80 (20,7)

320 (21,2)

1,0

34b

256 (35,6)

> 786 (> 42,3)

> 1,9

> 512 (> 25)

> 512 (> 11)

-

80 (20,7)

320 (21,2)

1,0

Internal control

41 (5,7)

106 (5,7)

1,0

62 (3)

140 (3)

1,0

22 (5,7)

86 (5,7)

1,0

  1. Laboratory Nr. 1 - Labor Enders, Stuttgart, Laboratory Nr. 2 - Robert Koch-Institute (RKI), Berlin, Laboratory Nr. 3 - Institute for Medical Virology, Johann Wolfgang Goethe-University of Frankfurt
  2. *Ratio of IU/ml Sabin to IU/ml CHAT
  3. **GMT Reciprocal geometric mean titers