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Table 1 Summary of Susceptibility Studies: Mice challenged with 1 ID50 after pre-treatment with test agent or control

From: Microbicide excipients can greatly increase susceptibility to genital herpes transmission in the mouse

Test Agent administered 12 h before viral challenge Fraction infected after Test Agent Fraction infected after PBS Control P value Fold-increase in susceptibility Osmolality (mOsm/kg)
Methylparaben/propylparaben (0.18%/0.02%) in HEC gel 19/60 (32%) 20/60 (33%) 1   374
Benzyl alcohol (1%) in HEC gel 26/60 (43%) 26/60 (43%) 1   338
Disodium EDTA (0.1%) in HEC gel 59/90 (66%) 52/90 (58%) 0.095 2* 376
Disodium EDTA (0.0186%) in HEC gel 10/60 (17%) 14/60 (23%) 0.49   341
Propylene glycol (10%) in HEC gel 38/60 (63%) 33/60 (55%) 0.46   1,770
Glycerin (10%) in HEC gel 15/60 (25%) 23/60 (38%) 0.17 2* 1,700
Glycerin (30%) in HEC gel 32/59 (54%) 20/59 (34%) 0.04 3 4,280
GML (5%) in K-Y Warming Jelly 59/60 (98%) 28/60 (47%)♦ < 0.0001 > 10 10,100
K-Y Warming Jelly (neat) 57/60 (95%)   < 0.0001 > 9 10,300
GML (5%) colloidal suspension in PBS 48/60 (80%) 33/60 (55%) 0.006 5 329
Propylene glycol (neat) 55/60 (92%) 28/59 (47%)♦ < 0.0001 10 9,990
Polyethylene glycol (PEG-8) (neat) 55/60 (92%)   < 0.0001 10 5,610
  1. ♦ Control for both agents in the adjacent column in a three-arm experiment.
  2. * Fold-increases were calculated for these formulations because of their strong, though not statistically significant, trends toward increased susceptibility.