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Table 1 Characteristics of three previously healthy patients with primary Influenza B infection, severe bacterial pneumonia and septic shock

From: Co-infection of Influenza B and Streptococci causing severe pneumonia and septic shock in healthy women

Characteristic Patient 1 Patient 2 Patient 3
Date of admission February 2008 March 2008 March 2008
Days of hospitalization 56 18 26
Age (years) 40 27 61
Co-morbidities None None Osteoporosis
Septic shock *    
   Tachycardia (beats/min) 160 120 110
   Tachypnoea (rate/min) 40 45 30
   Hypotension Yes Yes Yes
   Fever (°C) 40 39 39
   Leukocyte count (×10S9/l) 2.96 12.4 14.2
Microbiology    
   Initially isolated bacteria S. pyogenes S. pyogenes S. pneumoniae
   Influenza B RT-PCR § Positive Positive Positive
   Influenza A RT-PCR § Negative Negative Negative
Initial therapy Piperacillin/Tazobactam Amoxicillin/clavulanic acid plus Clarithromycin Ceftriaxon plus Clarithromycin
Final therapy Penicllin plus Penicillin plus Vancomycin plus
  Oseltamivir Oseltamivir Oseltamivir
Laboratory findings ||    
   CRP (mg/l) 507 445 329
   PCT (ng/ml) 203 113 3.71
Arterial blood gas ||    
   pH 7.19 7.28 7.45
   paO2 (kPa) 8.7 9.72 6.59
   paCO2 (kPa) 8.9 4.84 4.95
   BE -4.6 -8.8 2.5
   Lactate (mmol/l) 1.4 5.1 2.5
Death on day - 18 -
  1. * Defined as patients showing all of following abnormal findings: tachycardia, tachypnoe, fever, leukocytosis or -penia and hypotension. Data printed are from the time of admission.
  2. Results from bronchoalveolar lavage and blood cultures.
  3. Result from urine pneumococcal antigen test.
  4. § Real-time quantitative PCR from tracheal aspirate detecting Influenza A and B in separate reactions confirmed in at least two separate exams.
  5. || Values showing the greatest deviation from normal during the first two days after admission. All blood gas data were obtained while applying high flow oxygen through a non re-breathing mask.