Figure 3

Co-cultivation of mycobacteria with Cd36 ^-/- murine macrophages. In vitro, mycobacterial infection of thioglycolate-elicited peritoneal macrophages resulted in lower mycobacterial loads in cultures of Cd36 ^-/- macrophages (white box, dashed line) compared with wild type controls (black box, solid line). A. Infection with M. tuberculosis (MOI = 10:1) produced a progressive rise in mycobacterial counts over 7 days, with significant difference (p < 0.0001) between groups. B. Similar results were seen after infection with the rapidly growing M. marinum (MOI = 1:1, p < 0.001). Data are shown as mean +/- 95% CI with 4 to 6 replicates at each time.