Epidemiological study of phylogenetic transmission clusters in a local HIV-1 epidemic reveals distinct differences between subtype B and non-B infections

Table 1 Comparison of characteristics of patients infected with a subtype B virus and patients infected with a virus of the non-B subtypes.

	Subtype B	Non-B subtypes		Multivariate Bin. Log. Regression
	Count (%)	Count (%)	p-value	ODDS ratio	95% CI	p-value
# Patients (n = 506)	302 (59.7%)	204 (40.3%)
Homosexual transmission	229/271 (84.5%)	13/137 (9.5%)	< 0.001	33.1	14.5 - 75.6	< 0.001
HBV ⁺	106/296 (35.8%)	82/195 (42.1%)	0.164			-
HCV ⁺	26/295 (8.8%)	8/197 (4.1%)	0.042	9.1	1.5 - 56.2	0.017
Syphilis ⁺	119/300 (39.7%)	21/200 (10.5%)	< 0.001			-
Chlamydia ⁺	106/259 (40.9%)	21/126 (16.7%)	< 0.001	3.6	1.4 - 9.6	0.01
Gender (male)	279/302 (92.4%)	94/204 (46.1%)	< 0.001			-
Caucasian origin	285/299 (95.3%)	68/202 (33.7%)	< 0.001	21.0.	5.3 - 82.5	< 0.001
DRM	25/302 (8.3%)	8/204 (3.9%)	0.052			-
PHI	60/275 (21.8%)	12/189 (6.3%)	0.021			-
	Median (IQR)	Median (IQR)	p-value
CD4 ⁺ T cells (cells/μl)	420 (284-592)	330 (182-516)	< 0.001			-
Age (years)	38.5 (32-44)	36 (30-36)	0.018			-

Values are given as counts per number of patients for which data was available. For the multivariate analysis, odds ratios are given with regard to Subtype B infection. The p-value for the Hosmer-Lemeshow test for the multivariate model is 0.528.
HBV, Hepatitis B virus; HCV, Hepatitis C virus; DRM, Drug resistant mutations; PHI, Primary HIV infection; IQR, interquartile range; CI, confidence interval.

ISSN: 1471-2334