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Table 5 Results of a scenario analysis

From: Economic evaluation of pneumococcal conjugate vaccination in The Gambia

No.

Selected alternative scenarios

ICER (US$ per DALYa averted)

  

PCV7

PCV9 &10

PCV13

1

Immunity waning (no waning up to age 5, 25% decrease up to age 15, and 50% decrease up to age 30)

Serotype replacement (by 25%)

No herd immunity

4,110

1,220

1,010

2

No Immunity waning

Serotype replacement (by 25%)

No herd immunity

3,960

1,170

970

3

No Immunity waning

Serotype replacement (increased incidence of non-primary endpoint pneumonia among vaccinated)

No herd immunity

900

650

550

4

No Immunity waning

No serotype replacement

No herd immunity

670

490

410

5

No Immunity waning

Serotype replacement (increased incidence of non-primary endpoint pneumonia among vaccinated)

Herd immunity (assumed incidence decrease by 32%, 32%, 8%, and 18% for individuals aged 5-19 years, 20-39 years, 40-64 years, and 65 years and older)

830

550

480

6

No Immunity waning

No serotype replacement

Herd immunity (assumed incidence decrease by 32%, 32%, 8%, and 18% for individuals aged 5-19 years, 20-39 years, 40-64 years, and 65 years and older)

630

430

370

  1. DALY: disability-adjusted life year, ICER: incremental cost-effectiveness ratio.
  2. a DALYs calculated without age-weighting (K = 0).