Determinants of seropositivity among HPV-16/18 DNA positive young women

BMC Infectious Diseases

Table 5 Determinants of seropositivity among HPV-18 DNA positive women; Contraceptive, pregnancy, smoking status factors.

Women characteristics	Anti-HPV18			Unadjusted		Final model¹
	Negative	Positive	%	OR	(95% CI)	OR	(95% CI)
All women	76	103	57.5
Use of hormonal contraceptives
Never	17	14	45.2	1.00		1.00
In the past	19	18	48.7	1.15	(0.44-3.00)	1.15	(0.44-3.00)
Current oral contraceptives	31	63	67.0	2.47	(1.08-5.65)	2.47	(1.08-5.65)
Current injectable	9	8	47.1	1.08	(0.33-3.53)	1.08	(0.33-3.53)
Use of condom
Never	27	41	60.3	1.00		1.00
In the past	33	40	54.8	0.80	(0.41-1.56)	0.87	(0.43-1.74)
Current (last month)	16	22	57.9	0.91	(0.40-2.03)	1.19	(0.51-2.80)
Frequency of condom use
Never or rarely	31	50	61.7	1.00		1.00
Sometimes	10	13	56.5	0.81	(0.32-2.06)	0.80	(0.31-2.11)
Most of the time	15	18	54.6	0.74	(0.33-1.69)	0.93	(0.40-2.17)
Always	19	22	53.7	0.72	(0.34-1.53)	0.80	(0.37-1.76)
Use of condom last sexual intercourse
No	54	75	58.1	1.00		1.00
Yes	22	28	56.0	0.92	(0.47-1.77)	1.23	(0.60-2.56)
Number of pregnancies
0	38	44	53.7	1.00		1.00
1	25	39	60.9	1.35	(0.69-2.62)	1.35	(0.69-2.62)
2	11	13	54.2	1.02	(0.41-2.54)	1.02	(0.41-2.54)
≥ 3	2	7	77.8	3.02	(0.59-15.43)	3.02	(0.59-15.43)
p trend					0.29		0.29
Smoking Status
Never smoked for ≥ 6 months	56	75	57.3	1.00		1.00
Former smoker	3	8	72.7	1.99	(0.51-7.85)	1.99	(0.51-7.85)
Current	17	20	54.1	0.88	(0.42-1.83)	0.88	(0.42-1.83)
Cytology-Hybrid capture, viral load ²
Normal/Low viral load	34	45	57.0	1.00		1.00
LSIL-HSIL/Low viral load	4	8	66.7	1.51	(0.42-5.44)	1.51	(0.42-5.44)
Normal/High viral load	12	11	47.8	0.69	(0.27-1.76)	0.69	(0.27-1.76)
LSIL-HSIL/High viral load	24	36	60.0	1.13	(0.57-2.24)	1.13	(0.57-2.24)

NOTE. OR, odds ratio; CI, confidence interval; LSIL, low grade squamous intraepithelial lesion; HSIL, high grade squamous intraepithelial lesion; HPV, human papillomavirus.
¹ For each variable considered the final model adjusts for all variables that changed the crude estimate of risk by 15% or more.
Use of hormonal contraceptives: was not adjusted for any co-factors since none of the potential confounders evaluated changed the OR estimates by 15% or more.
Use of condom: was adjusted for use of hormonal contraceptives.
Frequency of condom use: was adjusted for use of hormonal contraceptives.
Use of condom last sexual intercourse: was adjusted for use of hormonal contraceptives.
Number of pregnancies, smoking status and cytology-hybrid capture, viral load: were not adjusted for any co-factors since none of the potential confounders evaluated changed the OR estimates by 15% or more.
² Low viral load defined as hybrid capture RLU/CO ≤ 30; High viral load defined as hybrid capture RLU/CO > 30.

ISSN: 1471-2334