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Table 3 Virucidal activity of glutardialdehyde against VACV and MVA virus depending on concentration and contact time

From: Can vaccinia virus be replaced by MVA virus for testing virucidal activity of chemical disinfectants?

  VACV RF (log10)
Biocide results lab 1 results lab 2 results lab 3
  0.5 min 2 min 5 min 0.5 min 2 min 5 min 0.5 min 2 min 5 min
0.05% glutardialdehyde 0.50 ± 0.34 4.06 ± 0.32 ≥4.82 ± 0.29 0.50 ± 0.44 3.88 ± 0.53 ≥5.38 ± 0.37 ≥3.86 ± 0.49 ≥4.43 ± 0.49 ≥4.58 ± 0.49
0.1% glutardialdehyde 2.75 ± 0.39 ≥3.82 ± 0.29 ≥3.82 ± 0.29 2.13 ± 0.49 ≥5.38 ± 0.37 ≥5.38 ± 0.37 ≥3.86 ± 0.39 ≥3.86 ± 0.39 ≥3.86 ± 0.39
0.5% glutardialdehyde ≥2.82 ± 0.29 ≥2.82 ± 0.29 ≥2.82 ± 0.29 ≥5.38 ± 0.37 ≥5.38 ± 0.37 ≥5.38 ± 0.37 ≥4.0 ± 0.35 ≥4.0 ± 0.35 ≥4.0 ± 0.35
  MVA RF (log 10 )
Biocide results lab 1 results lab 2 results lab 3
  0.5 min 2 min 5 min 0.5 min 2 min 5 min 0.5 min 2 min 5 min
0.05% glutardialdehyde 1.38 ± 0.41 ≥3.88 ± 0.42 ≥4.50 ± 0.38 0.19 ± 0.56 2.07 ± 0.48 ≥4.19 ± 0.43 1.86 ± 0.53 ≥3.14 ± 0.40 ≥3.14 ± 0.40
0.1% glutardialdehyde 2.81 ± 0.38 ≥4.00 ± 0.38 ≥4.00 ± 0.38 0.69 ± 0.51 ≥4.32 ± 0.35 ≥4.32 ± 0.35 ≥3.14 ± 0.40 ≥3.14 ± 0.40 ≥3.14 ± 0.40
0.5% glutardialdehyde ≥3.50 ± 0.38 ≥3.50 ± 0.38 ≥3.50 ± 0.38 ≥3.32 ± 0.35 ≥3.32 ± 0.35 ≥3.32 ± 0.35 ≥3.14 ± 0.40 ≥3.14 ± 0.40 ≥3.14 ± 0.40
  1. The prefix "≥" indicates that the determination of the RF is limited by cytotoxic reactions and/or the amount
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BMC Infectious Diseases

ISSN: 1471-2334

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