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Table 3 Virucidal activity of glutardialdehyde against VACV and MVA virus depending on concentration and contact time

From: Can vaccinia virus be replaced by MVA virus for testing virucidal activity of chemical disinfectants?

 

VACV RF (log10)

Biocide

results lab 1

results lab 2

results lab 3

 

0.5 min

2 min

5 min

0.5 min

2 min

5 min

0.5 min

2 min

5 min

0.05% glutardialdehyde

0.50 ± 0.34

4.06 ± 0.32

≥4.82 ± 0.29

0.50 ± 0.44

3.88 ± 0.53

≥5.38 ± 0.37

≥3.86 ± 0.49

≥4.43 ± 0.49

≥4.58 ± 0.49

0.1% glutardialdehyde

2.75 ± 0.39

≥3.82 ± 0.29

≥3.82 ± 0.29

2.13 ± 0.49

≥5.38 ± 0.37

≥5.38 ± 0.37

≥3.86 ± 0.39

≥3.86 ± 0.39

≥3.86 ± 0.39

0.5% glutardialdehyde

≥2.82 ± 0.29

≥2.82 ± 0.29

≥2.82 ± 0.29

≥5.38 ± 0.37

≥5.38 ± 0.37

≥5.38 ± 0.37

≥4.0 ± 0.35

≥4.0 ± 0.35

≥4.0 ± 0.35

 

MVA RF (log 10 )

Biocide

results lab 1

results lab 2

results lab 3

 

0.5 min

2 min

5 min

0.5 min

2 min

5 min

0.5 min

2 min

5 min

0.05% glutardialdehyde

1.38 ± 0.41

≥3.88 ± 0.42

≥4.50 ± 0.38

0.19 ± 0.56

2.07 ± 0.48

≥4.19 ± 0.43

1.86 ± 0.53

≥3.14 ± 0.40

≥3.14 ± 0.40

0.1% glutardialdehyde

2.81 ± 0.38

≥4.00 ± 0.38

≥4.00 ± 0.38

0.69 ± 0.51

≥4.32 ± 0.35

≥4.32 ± 0.35

≥3.14 ± 0.40

≥3.14 ± 0.40

≥3.14 ± 0.40

0.5% glutardialdehyde

≥3.50 ± 0.38

≥3.50 ± 0.38

≥3.50 ± 0.38

≥3.32 ± 0.35

≥3.32 ± 0.35

≥3.32 ± 0.35

≥3.14 ± 0.40

≥3.14 ± 0.40

≥3.14 ± 0.40

  1. The prefix "≥" indicates that the determination of the RF is limited by cytotoxic reactions and/or the amount