Pharmacokinetic-pharmacodynamic profiling of four antimicrobials against Gram-negative bacteria collected from Shenyang, China

Table 3 Bactericidal cumulative fractions of response (CFRs) for antibiotic dosage regimens against Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, Pseudomonas aeruginosa and Acinetobacter baumannii collected from Shenyang in China

Regimen	Bactericidal CFR (%)
	E. coli	K. pneumoniae	E. cloacae	P. aeruginosa	A. baumannii
Meropenem 0.5 g q6h	100	100	100	52	59
Meropenem 0.5 g q8h	100	100	97	46	59
Meropenem 1 g q8h	100	100	100	54	59
Imipenem 0.5 g q6h	100	99	97	45	36
Imipenem 0.5 g q8h	100	97	97	36	34
Imipenem 1 g q8h	100	99	98	49	37
Cefepime 1 g q8h	90	73	68	48	22
Cefepime 2 g q8h	95	83	78	68	37
Cefepime 2 g q12h	90	74	68	45	22
Piperacillin/tazobactam 4.5 g q8h	71	33	34	11	8
Levofloxacin 0.5 g every 24 h	30	44	68	33	19

ISSN: 1471-2334