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Table 4 Allele richness (R s ), expected heterozygosity (H e ) and F S T estimates at flanking and neutral microsatellites of P. falciparum dhfr double and triple mutants

From: Tracing the origins and signatures of selection of antifolate resistance in island populations of Plasmodium falciparum

  

dhfrgenotypes

Microsatellites

Double mutant (N= 52)

Triple mutant (N= 99)

all samples (N= 151)

  

R s

H e

R s

H e

R s

H e

F ST

P

Loci flanking dhfr gene

Dhfr 0.3

8

0.34

7

0.68

9

0.51

0.38

<0.0001

 

Dhfr 4.4

8

0.48

6

0.45

7

0.46

-0.01

NS

 

Dhfr 5.3

6

0.35

6

0.37

7

0.36

0.57

<0.0001

 

All loci

7

0.39

6

0.50

8

0.44

0.37

<0.0001

Loci flanking dhps gene

Dhps 0.8

12

0.67

10

0.53

13

0.60

0.01

NS

 

Dhps 4.3

8

0.70

7

0.67

8

0.69

0.01

NS

 

Dhps 7.7

14

0.92

15

0.90

17

0.91

-0.01

NS

 

All loci

11

0.76

11

0.70

13

0.73

0.00

NS

Neutral loci

TAA81

8

0.83

11

0.84

10

0.83

0.02

NS

 

TA109

10

0.76

11

0.72

11

0.74

0.01

NS

 

TA87

11

0.89

12

0.85

12

0.87

0.01

NS

 

PfPK2

10

0.85

13

0.88

13

0.87

-0.01

NS

 

All loci

10

0.83

12

0.82

12

0.83

0.01

NS

  1. N: Number of isolates genotyped. All loci: mean over loci R s and H e and global F ST over loci as calculated by FSTAT. P: P-values of permutation tests to assess significance of F ST values. NS: non-significant (P > 0.05). In bold: significant after Bonferroni corrections for multiple tests.
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BMC Infectious Diseases

ISSN: 1471-2334

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