Clinical features and predictors of mortality in admitted patients with community- and hospital-acquired legionellosis: A Danish historical cohort study

Table 5 Independent predictors of 30 day mortality in patients with CAL.^a

	CAL
Predictor variables by category	Odds ratio (95% conf. interval)	P-value
Demographics
Age > 65 years	1.3 (0.5-3.7)	0.60
Case associated with travelling to another country	0.4 (0.1-1.4)	0.16
Comorbid illnesses
Charlson Comorbidity Index ≥ 2	2.8 (0.9-8.5)	0.08
Current smoker	0.7 (0.2-2.0)	0.46
Symptoms
Self-reported fever	0.7 (0.2-2.3)	0.51
Dyspnoea	1.6 (0.6-4.3)	0.40
Headache	0.1 (0.01-1.03)	0.05
Confusion	3.0 (0.98-9.2)	0.06
Signs
Normal pulmonary stethoscopy	0.3 (0.05-1.6)	0.16
Laboratory tests
Lymphocytosis, lymphocyte count >3.5 cells 10⁹/L	33.9 (2.1-553.5)	0.01*
Bilirubin >23 mikromol/L	7.3 (1.6-33.4)	0.01*
Blood urea nitrogen >7.5 mmol/L	1.9 (0.4-8.5)	0.38
Hyponatriemia, sodium <128 mmol/L	0.2 (0.04-0.8)	0.03*
Hypercapnia, PaCO2 >6 kPa	2.4 (0.3-20.4)	0.42
Fibrillatrio atriorum at admission	2.4 (0.6-9.6)	0.22
Treatment
Treatment with anti-legionella antibiotics < 24 hours from baseline^b	0.3 (0.1-1.6)	0.16
Model without symptoms and laboratory tests
	*CAL*
*Predictor variables by category*	*Odds ratio (95% conf. interval)*	*P-value*
Demographics
Age > 65 years	2.6 (1.1-5.9)	0.02*
Case associated with travelling to another country	0.5 (0.2-1.3)	0.15
Comorbid illnesses
Charlson Comorbidity Index ≥ 2	2.7 (1.1-6.5)	0.03*
Current smoker	0.8 (0.3-1.9)	0.56
Signs
Normal pulmonary stethoscopy	0.3 (0.1-1.2)	0.09
Treatment
Treatment with anti-legionella antibiotics < 24 hours from baseline^b	0.4 (0.1-1.7)	0.21

a For community-acquired cases 30 days from admission. For hospital-acquired cases 30 days from onset of symptoms
b For community-acquired cases time from admission. For hospital-acquired cases time from beginning of symptoms.
* P-level < 0.05 is considered statistically significant

ISSN: 1471-2334