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Table 1 Baseline subject characteristics, overall and by significant fibrosis as determined by AST-to-platelet ratio index (APRI) score (APRI >1.5).

From: Prevalence and risk factors for significant liver fibrosis among HIV-monoinfected patients

Characteristic All Subjects (n = 432) APRI ≤ 1.5 (n = 396) APRI >1.5 (n = 36) P-Value
Median age (yrs, IQR) 38 (32-44) 38 (31-44) 39 (35-45) 0.4
Male sex (no., %) 254 (59%) 228 (58%) 26 (72%) 0.09
Race (no., %)     
   African-American 311 (72%) 286 (72%) 25 (69%) 0.7
   Caucasian 121 (28%) 110 (28%) 11 (31%)  
Hispanic (no., %) 17 (4%) 16 (4%) 1 (3%) 0.7*
Alcohol use in last 30 days (no., %) 185 (43%) 167 (42%) 18 (50%) 0.4
Marijuana use in last 30 days (no., %) 81 (19%) 72 (18%) 9 (25%) 0.3
Diabetes mellitus (no., %) 34 (8%) 28 (7%) 6 (17%) 0.04
Body mass index (kg/m 2 , IQR)     0.1*
   Underweight (≤ 18.4 kg/m2) 15 (3%) 14 (4%) 1 (3%)  
   Ideal (18.5 kg/m2 - 24.9 kg/m2) 202 (47%) 179 (45%) 23 (64%)  
   Overweight (25.0 kg/m2 - 29.9 kg/m2) 135 (31%) 128 (32%) 7 (19%)  
   Obese (30 kg/m2 - 39.9 kg/m2) 65 (15%) 60 (15%) 5 (14%)  
   Very Obese (≥ 40.0 kg/m2) 15 (3%) 15 (4%) 0  
Median duration of HIV (yrs, IQR) 2 (1-7) 2 (0-7) 2 (0-9.5) 0.8
On antiretroviral therapy (no., %) 273 (63%) 252 (63%) 21 (58%) 0.5
Lopinavir/ritonavir (no., %)     
   Prior 175 (41%) 159 (40%) 16 (44%) 0.6
   Current 74 (17%) 68 (17%) 6 (17%) 0.9
Nevirapine (no., %)     
   Prior 67 (16%) 61 (15%) 6 (17%) 0.8
   Current 12 (3%) 12 (3%) 0 (0%) 0.3*
Didanosine (no., %)     
   Prior 57 (13%) 55 (14%) 2 (6%) 0.2*
   Current 11 (3%) 11 (3%) 0 (0%) 0.3*
Stavudine (no., %)     
   Prior 84 (19%) 78 (20%) 6 (17%) 0.7
   Current 11 (3%) 5 (2%) 0 (0%) 0.5*
Zidovudine/lamivudine/abacavir (no., %)     
   Prior 35 (8%) 33 (8%) 2 (6%) 0.6
   Current 8 (2%) 8 (2%) 0 (0%) 0.4
Median CD4 count (cells/mm 3 , IQR) 340 (177-516) 342 (182-516) 315 (58-534) 0.3
CD4 count <200 cells/mm 3 (no., %) 121 (28%) 107 (27%) 14 (39%) 0.1
Median HIV viral load (copies/mL, IQR) 4,950 (75-44,162) 2,506 (75-33,228) 38,517 (2,958-206,373) 0.0004
HIV viral load category (no., %)     
   75-49,999 copies/mL 331 (76%) 311 (78%) 20 (56%) 0.003*
   50,000-99,999 copies/mL 33 (8%) 30 (8%) 3 (8%)  
   ≥ 100,000 copies/mL 68 (16%) 55 (14%) 13 (36%)  
Detectable HIV viremia (>75 copies/mL) 323 (75%) 291 (73%) 32 (89%) 0.04
Median aspartate aminotransferase (U/L, IQR) 39 (23-42) 29 (23-37) 84 (65-123) <0.001
Median platelet count (×10 9 /L, IQR) 232 (187-283) 237 (197-287) 130 (92-163) <0.001
Median APRI 0.42 (0.31-0.66) 0.40 (0.30-0.59) 2.1 (1.7-80-3.64) <0.001
  1. * P-values for differences between subjects determined by Fisher's exact test
  2. IQR = interquartile range