pncA mutations in clinical Mycobacterium tuberculosisisolates from Korea

BMC Infectious Diseases

Table 1 pncA nucleotide and amino acid changes in PZase-negative M. tuberculosis clinical isolates from Korea

Mutation	Nucleotide	Amino acid	No. of
site	changes	changes	isolates
-11	A to G^b	Mutation in promoter	3
23	TCG insertion	Slipped-strand mispairing	1
41	G41A	Missense (Cys14 Tyr)	1
56	234-bp deletion	Frameshift	1
172	T172C^c	Missense (Phe58 Leu)	1
190	T190G	Missense (Tyr64 Asp)	1
212	A212G^d	Missense (His71 Arg)	1
227	C227T^e	Missense (Thr76 Ile)	1
317	CT insertion	Frameshift	1
382	AG insertion	Frameshift	1
393	GT insertion	Frameshift	1
393	T insertion	Frameshift	1
395	G395T	Missense (Gly132 Val)	2
403	A403C^d	Missense (Thr135 Pro)	1
407	A407G	Missense (Asp136 Gly)	1
421	C421T	Nonsense (Gln141 Termination)	1
425, 180^a	C425T^f, C180T	Missense (Thr142 Met), Silent (Gly60 Gly)	1
513	GC deletion	Frameshift	1

^a Two point mutations, including silent one, in a single strain. ^b Previously described mutation [4, 9, 11, 14, 16]. ^c Previously described mutation [16]. ^d Previously described mutations [13]. ^e Previously described mutation [15]. ^f Previously described mutation [5, 14].

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