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Table 1 Abnormal accumulation of PrP at various post inoculation stages.

From: Blood borne transit of CJD from brain to gut at early stages of infection

Abnormal PrP

CJD:days pi

 

NORMAL:days pi

TISSUE (route)

2

4

14

28*–32

42

70*

90*–120

>170*

2

32

240

central

           

Brain (ic)

-

-

-

-

-

-

+

na

-

-

-

Spinal cord (ic)

-

-

-

-

-

-

+

na

-

-

-

Brain (ip)

-

-

-

-

-

-

-

+

-

-

-

Spinal cord (ip)

-

-

-

-

-

-

-

+

-

-

-

peripheral

           

Peyer's Patch (ic)

-

-

-

+

+

+

+

na

-

-

-

Lymph node (ic)

-

-

-

+

+

+

+

na

-

-

-

Spleen (ic)

-

-

-

+

+

+

+

na

-

-

-

Lymph nodes (ip)

-

-

-

+

nd

+

+

+

-

nd

-

Spleen (ip)

-

-

-

+

+

+

+

+

-

-

-

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BMC Infectious Diseases

ISSN: 1471-2334

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