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Table 4 Statistical comparison on the performance of the 3 methods used

From: CMV infection of liver transplant recipients: comparison of antigenemia and molecular biology assays

    specificity Sensitivity a) PPV NPV
   Antigenemia pp65 67% 80% 63% 49%
  globally CMV Monitor 63% 90% 69% 57%
Without   pp67 mRNA b) 76% 85% 88% 58%
cut-off   Antigenemia pp65 62% - 30% 73%
  Before      
   CMV Monitor 64% - 28% 74%
  treatment      
   pp67 mRNA b) 79% - 60% 76%
   Antigenemia pp65 93% 65% 94% 54%
  globally CMV Monitor 86% 90% 89% 59%
With   pp67 mRNA b) - - - -
cut-off   Antigenemia pp65 91% - 80% 77%
  Before      
   CMV Monitor 87% - 57% 78%
  treatment      
   pp67 mRNA b) - - - -
  1. a) No determinations were available before beginning of treatment since this variable requires a disease event b) No cut-off value could be used due to the method's qualitative nature