Table 4 Predictive factors of first-line antibiotic treatment failure.
From: Bacterial infection profiles in lung cancer patients with febrile neutropenia
Failure n = 24 n (%) | Success n = 63 n (%) | p value | |
|---|---|---|---|
Mean age (years) | 69.2 | 62.33 | <0.001 |
Age >60 years | 20 (83.3) | 32 (50.8) | 0.007 |
WHO Score ≥2 | 20 (83.3) | 34 (54) | 0.024 |
No. of comorbidities>2 | 4 (16.7) | 7 (11.1) | 0.487 |
Diabetes | 7 (29.2) | 10 (15.9) | 0.225 |
Corticosteroid treatment | 9 (37.5) | 15 (23.8) | 0.283 |
Pulmonary antecedents | 15 (62.5) | 43 (68.3) | 0.800 |
COPD | 14 (58.3) | 32 (50.8) | 0.470 |
Severe COPD (FEV1<30% theory) | 1 (4.2) | 2 (3.2) | 1 |
Small cell cancer | 6 (25) | 17 (27) | 1 |
More than 1 chemotherapy | 4 (16.7) | 10 (15.9) | 1 |
Metastases | 18 (75) | 36 (57.1) | 0.145 |
Radiotherapy associated | 6 (25) | 19 (30.2) | 0.793 |
G-CSF preventive | 4 (16.7) | 13 (20.6) | 0.771 |
G-CSF curative | 12 (50) | 19 (30.2) | 0.132 |
Already hospitalized patient | 7 (29.2) | 5 (7.9) | 0.017 |
Altered general status | 17 (70.8) | 30 (47.6) | 0.059 |
Dehydration | 14 (58.3) | 20 (31.7) | 0.029 |
Gravity signs at admission | 15 (62.5) | 29 (46) | 0.231 |
Delayed treatment | 6 (25) | 12 (19) | 0.562 |
Neutropenia > 8 days | 3 (12.5) | 6 (9.5) | 0.702 |
Neutrophils count <100/mm3 | 7 (29.2) | 13 (20.6) | 0.354 |
Haemoglobin <8 g/dl | 9 (37.5) | 32 (50.8) | 0.465 |
Platelets < 20000/mm3 | 10 (41.7) | 8 (12.7) | 0.006 |
Decreasing of CRP | 8 (33.3) | 32 (50.8) | 0.002 |
Undetermined origin of fever | 6 (25) | 34 (54) | 0.018 |
Clinically documented fever (without microbiological documentation) | 6 (25) | 8 (12.7) | 0.196 |
Microbiologically documented fever | 12 (50) | 21 (33.3) | 0.216 |
Respiratory signs | 6 (25) | 15 (23.8) | 0.203 |
Bacteraemia | 9 (37.5) | 11 (17.5) | 0.277 |
Gram negative bacilli | 10 (41.7) | 9 (14.2) | 0.03 |
Multidrug resistant bacteria in patient with at least one strain documented | 4 (33.3) | 2 (9.5) | 0.159 |
Antibiotic treatment in last 6 month | 6 (25) | 16 (25.8) | 1 |
Out patient first antibiotic treatment | 4 (16.7) | 10 (15.9) | 1 |
Appropriateness between microbiology and antibiotherapy in patient with at least one strain documented | 7 (58.3) | 21 (100) | 0.003 |