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Table 5 Acute period outcomes (28 days following index) across periods of Omicron subvariants prevalence

From: Characteristics and outcomes of COVID-19 patients presumed to be treated with sotrovimab in NHS hospitals in England

Outcome

Period 1

(BA.1 predominant, BA.2 < 25% prevalence)

(n = 2102)

Period 2

(25% > BA.2

< 75% prevalence)

(n = 993)

Period 3

(BA.2 > 75% prevalence)

(n = 3884)

Period 4

(BA.5 < 25% prevalence)

(n = 573)

Period 5

(25% > BA.5

< 75% prevalence)

(n = 1161)

Period 6

(BA.5 > 75% prevalence)

(n = 1383)

COVID-19-attributable hospitalization, n (%)

22 (1.0)

13 (1.3)

37 (1.0)

6 (1.0)

16 (1.4)

10 (0.7)

Incidence rate per 100 patient-days

0.040

0.050

0.036

0.040

0.052

0.028

Incidence rate ratioa

(95% CI)

REF

1.16

(0.58–2.31)

0.76

(0.44–1.30)

0.8

(0.32–1.99)

1.07

(0.56–2.06)

0.56

(0.26–1.19)

P-value

REF

0.67

0.31

0.63

0.83

0.13

  1. a Incidence of hospitalization = (hospitalizations observed/total person time in days) × 100
  2. CI, confidence interval; COVID-19, coronavirus disease 2019; REF, reference group