Study (year) | Country | Age at enrollment (Median (IQR)/Mean (SD)) | WHO clinical stage of HIV | CD4+ at enrollment (Median (IQR)/ Mean (SD) cells/mm3) | Viral load level at enrollment (Log copies) | Intervention |
---|---|---|---|---|---|---|
Connor 1994 [41] | France, The USA | 25* | - | No. with 200-500 cells:187 | NR | 1. ZDV 2. PLC |
No. with less than 500 cells: 272 | ||||||
The Petra study team 2002 | Uganda, Tanzania, South Africa | 26 (22-30) | Stage 3 or 4: 22 (6%) | 455.8 (247.7) | NR | 1. ZDV/3TC 2. PLC |
The Kesho Bora Study group 2010 | Kenya west, South Africa | 27 (24-31) | Stage 1, 2 or 3: 824 (100%) | 336 | 4.2 | 1. ZDV/3TC/LPV/r 2. ZDV |
Koss 2014 [33] | Uganda | 29 (25-33) | Stage 1: 373 (96%) | 368 (163.5) | 4.2 | 1. ZDV/3TC/LPV/r 2. EFV/3TC/ZDV |
João 2020 [42] | Argentina, Brazil, South Africa, Tanzania, Thailand, The USA | 27 (22-32) | - | 395 (262-574) | 4.1 | 1. RAL/3TC/ZDV 2. EFV/3TC/ZDV |
Kintu 2020 [35] | South Africa, Uganda | 27.7 (5.2) | - | 446 (296-633) | 4.4 | 1. DTG/TDF/FTC (3TC) 2. EFV/TDF/FTC (3TC) |
Lockman 2021 [43] | Botswana | 26.6 (22.5-31.6) | - | 466 (308-624) | 3 | 1. DTG/TDF/FTC 2. EFV/TDF/FTC |
Brazil, India, South Africa, Tanzania, Thailand, Uganda | ||||||
The USA, Zimbabwe | ||||||
Shapiro 2010 [37] | Bostwana | 26.8 (5.94) | No AIDS defining disease | 404 (297-514) | 4.3 | 1. ZDV/3TC/ABC 2. ZDV/3TC/LPV/r |
Tubiana 2013 [39] | France | - | 500 (186) | 3.4 | 1. LPV/r 2. ZDV/3TC/LPV/r | |
Natureeba 2014 [38] | Tororo, Uganda | 29.25 (5.4) | Stage 1: 370 (95.1%) | 380.8 (162.5) | 4.1 | 1. ZDV/3TC/LPV/r 2. EFV/TDF/FTC |
Stage 2: 18 (4.6%) | ||||||
Stage 3:1 (0.3%) | ||||||
Lallemant 2015 [40] | Thailand | 27 (23-32) | Stage 1: 100% | 453 (363-577) | 4 | 1. ZDV 2. ZDV/LPV/r |
Fowler 2016 [31] | India, Malawi, South Africa, Tanzania, Uganda, Zambia, Zimbabwe | 26 (22-30) | Stage 1: 2,981 (96.5%) | 530 (436-663) | 3.9 | 1. ZDV 2. ZDV/3TC/LPV/r 3. TDF/FTC/LPV/r |
Waitt 2019 [34] | Uganda, South Africa | 26 (5.75) | - | 406.5 (207.2) | 4.5 | 1. DTG/TDF/FTC 2. EFV/TDF/FTC |