| AUC (95%CI) | Cutoff value | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | P value | P value (vs. CRP) | P value (vs. PCT) | |
---|---|---|---|---|---|---|---|---|---|---|
Healthy Controls vs. Infection | Â | |||||||||
LDNs (%) | 0.942 (0.888–0.996) | > 0.900 | 90.91 | 87.50 | 88.24 | 93.33 | < 0.001 | 0.536 | 0.222 | |
M-MDSCs (%) | 0.726 (0.586–0.866) | > 0.913 | 51.52 | 100.0 | 100.0 | 68.09 | 0.002 | 0.002 | 0.076 | |
PMN-MDSCs (%) | 0.908 (0.833–0.983) | > 0.788 | 84.85 | 90.63 | 90.32 | 87.88 | < 0.001 | 0.226 | 0.587 | |
MDSCs (%) | 0.904 (0.815–0.993) | > 1.454 | 90.91 | 90.63 | 90.91 | 93.55 | < 0.001 | 0.247 | 0.658 | |
CRP (mg/L) | 0.967 (0.912–1.023) | > 3.565 | 93.94 | 96.88 | 96.88 | 96.88 | < 0.001 | - | 0.033 | |
PCT (ng/mL) | 0.873 (0.776–0.970) | > 0.032 | 87.88 | 87.50 | 87.88 | 90.32 | < 0.001 | 0.033 | - | |
Healthy Controls vs. Sepsis | Â | |||||||||
LDNs (%) | 0.908 (0.845–0.971) | > 1.085 | 82.69 | 90.63 | 93.48 | 74.36 | < 0.001 | 0.004 | 0.011 | |
M-MDSCs (%) | 0.863 (0.779–0.947) | > 0.927 | 75.00 | 100.0 | 100.0 | 69.57 | < 0.001 | 0.002 | 0.003 | |
PMN-MDSCs (%) | 0.938 (0.891–0.986) | > 0.834 | 90.38 | 90.63 | 94.00 | 82.86 | < 0.001 | 0.011 | 0.030 | |
MDSCs (%) | 0.966 (0.930–1.001) | > 1.428 | 92.31 | 90.63 | 94.12 | 85.29 | < 0.001 | 0.073 | 0.183 | |
CRP (mg/L) | 0.998 (0.994–1.002) | > 7.870 | 98.08 | 100.0 | 100.0 | 94.12 | < 0.001 | - | 0.349 | |
PCT (ng/mL) | 0.992 (0.978–1.005) | > 0.071 | 96.15 | 96.88 | 98.04 | 91.18 | < 0.001 | 0.349 | - | |
Infection vs. Sepsis | Â | |||||||||
LDNs (%) | 0.617 (0.499–0.736) | > 14.20 | 38.46 | 90.91 | 90.91 | 57.69 | 0.053 | 0.082 | 0.001 | |
M-MDSCs (%) | 0.696 (0.583–0.809) | > 3.962 | 46.15 | 87.88 | 82.14 | 49.12 | 0.001 | 0.466 | 0.025 | |
PMN-MDSCs (%) | 0.642 (0.525–0.759) | > 11.56 | 42.31 | 87.88 | 84.62 | 49.15 | 0.017 | 0.150 | 0.002 | |
MDSCs (%) | 0.708 (0.597–0.819) | > 11.28 | 53.85 | 84.85 | 84.85 | 53.85 | < 0.001 | 0.567 | 0.026 | |
CRP (mg/L) | 0.749 (0.643–0.854) | > 78.21 | 65.38 | 78.79 | 85.37 | 61.36 | < 0.001 | - | 0.049 | |
PCT (ng/mL) | 0.851 (0.765–0.936) | > 0.410 | 76.92 | 87.88 | 90.91 | 70.73 | < 0.001 | 0.049 | - |