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Table 3 Reduction of MICs of β-lactam antibiotics combined with Monolaurin (500 µg/ml) against MRSA (n = 103)

From: Novel synergistic interactions between monolaurin, a mono-acyl glycerol and β lactam antibiotics against Staphylococcus aureus: an in vitro study

MIC (µg/mL)

FIC (A) / FIC (B)

FIC index

Interpretation

No. of isolates

P value

Alone

In combination

Ampicillin (A) /Monolaurin(B)

Ampicillin (A) /Monolaurin (B)

8/1000

0.5/500

0.0625/0.5

0.56

Partial synergy

24

 < 0.001

8/250

0.5/500

0.062/2

2.062

Indifference

3

8/500

2/500

0.25/1

1.25

Indifference

9

8/1000

2/500

0.25/0.5

0.75

Partial synergy

2

16/1000

0.5/500

0.03125/0.5

0.53

Partial synergy

28

16/1000

2/500

0.125/0.5

0.625

Partial synergy

4

32/1000

0.5/500

0.015625/0.5

0.515

Partial synergy

22

32/1000

2/500

0.0625/0.5

0.5625

Partial synergy

3

32/2000

2/500

0.0625/0.125

0.1875

Synergistic

8

Amoxicillin /Monolaurin

Amoxicillin /Monolaurin

FICA/FICB

FIC index

Interpretation

No.of isolates

P value

32/250

0.5/500

0.015625/2

2.015

Indifference

3

 < 0.001

32/1000

0.5/500

0.015625/0.5

0.515

Partial synergy

20

32/1000

4/500

0.125/0.5

0.625

Partial synergy

6

64/500

0.5/500

0.0078/1

1.0078

Indifference

9

64/1000

0.5/500

0.0078/0.5

0.5078

Partial synergy

44

64/1000

1/500

0.015625/0.5

0.515

Partial synergy

5

64/1000

4/500

0.0625/0.5

0.5625

Partial synergy

6

128/1000

0.5/500

0.0039/0.5

0.5039

Partial synergy

2

128/2000

0.5/500

0.0039/0.25

0.2539

Synergistic

8

Piperacillin /Monolaurin

Piperacillin /Monolaurin

FICA/FICB

FIC index

Interpretation

No. of isolates

P value

16/250

1/500

0.0625/2

2.0625

Indifference

2

 < 0.001

16/250

0.5/500

0.03125/2

2.03125

Indifference

1

16/1000

0.5/500

0.03125/0.5

0.53125

Partial synergy

25

64/500

0.5/500

0.0078/1

1.0078

Indifference

5

64/500

1/500

0.0156/1

1.0156

Indifference

4

128/1000

1/500

0.0078/0.5

0.5078

Partial synergy

16

128/1000

8/500

0.0625/0.5

0.5625

Partial synergy

12

128/1000

0.5/500

0.0039/0.5

0.5039

Partial synergy

12

128/1000

1/500

0.0078/0.5

0.5078

Partial synergy

6

128/1000

16/500

0.125/0.5

0.625

Partial synergy

12

256/2000

8/500

0.03125/0.25

0.28

Synergistic

8

  1. *total synergistic (FICI≤0.5), partial synergistic (0.5 < FICI < 1), additive FICI=1 or indifferent (1 < FICI < 4 and antagonistic (FICI≥4)
  2. **significant difference atPvalue < 0.05
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BMC Infectious Diseases

ISSN: 1471-2334

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