Biomarkers | Estimated change over time on cART (per year) | P value |
---|---|---|
CD4+ count | 43.9 cells per μl (95% CI 43.1 to 44.6) | <0.001 |
CD8+ count | −27.9 cells per μl (95% CI −28.6 to −27.2) | <0.001 |
CD4:CD8 ratio | 0.06 (95% 0.06 to 0.07) | <0.001 |
Viral load | −0.1 log10 copies per ml (95% CI −0.1 to −0.1) | <0.001 |
Biomarkers | Estimated mean of difference in change of biomarkers between cART-treated patients developing TB vs. those who remained free of TB | P value |
CD4+ count | −33 cells per μl (95% CI −44.6 to 21.2) | 0.001 |
CD8+ count | −72 cells per μl (95% CI −84.6 to 1.7) | 0.1 |
CD4:CD8 ratio | −0.01 (95% CI −0.03 to 0.01) | 0.2 |
Viral load | 0.01 log10 copies per ml (−0.04 to 0 .06) | 0.7 |