Fig. 1

Sequence of surgical procedures and X-ray image and Animal models for induction of osteomyelitis. Left: Sequence of surgical procedures and X-ray image. Osteomyelitis animal models used 18G needle as implant and injecting methicillin-sensitive Staphylococcus aureus suspension into bone marrow canal as an infection model. The X-ray image showed that needle completely inserted into femur of rats. Right: Animal models for induction of osteomyelitis. a Uninfected group (left leg); (b) Uninfected group (right leg); (c) Osteomyelitis group (left leg): 10 days after induction of infection; (d) Osteomyelitis group (right leg): 10 days after induction of infection; (e) Osteomyelitis group (left leg): 40 days after induction of infection; (f) Osteomyelitis group (right leg): 40 days after induction of infection