Table 1 Summary of pncA polymorphisms of all 57 strains with interpretable PZA DST results
Strain | Nucleotide | Substitution | DST+[Z]a | MTB lineageb | MLVA 15–9 type | Previously reported | Categoryc |
|---|---|---|---|---|---|---|---|
12-14129 | T14C | Ile5Thr | MDR+[R] | Haarlem | 15898-15 | No | − |
12–17,889 | A16C | Ile 6 Leu | MDR+[S] | Beijing K1 | 1065–32 | Yes [10] | C |
12–15893 | T20C | Val7Ala | XDR+[R] | Beijing K1 | 1065–32 | − | |
12–16359 | T40C | Cys14Arg | MDR+[R] | Beijing V+/CHIN+ | ?-32 | A | |
13–1786 | G41A | Cys14Tyr | XDR+[R] | Beijing V+/CHIN+ | 100–32 | − | |
12–16734 | A146C | Asp49Ala | MDR+[R] | Beijing V+/CHIN+ | 100–32 | A | |
12–16077 | A188C | Asp63Ala | MDR+[R] | Beijing V+/CHIN+ | 100–32 | D | |
12–16119 | G204 T | Trp68Cys | MDR+[R] | Haarlem | 2943–31 | Yes [10] | A |
12–17593 | C211T | His71Tyr | MDR+[R] | Beijing V+/CHIN+ | 100–32 | A | |
12–14879 12–17704 12–19027 12–19131 | A212C | His71Pro | MDR+[R] | Beijing K1 | 94–32 | Yes [37] | − |
13–774 | A212G | His71Arg | MDR+[R] | Beijing V+/CHIN+ | 1047–32 | A | |
12–15175 12–17995 12–18248 12–16269 | A212G | His71Arg | M(X)DR+[R] | Beijing K1 | 94–32 | See above | See above |
12–13963 | T254G | Leu85Arg | MDR+[R] | Beijing K1 | 407–32 | A | |
12–14551 | G356 T | Trp119Leu | MDR+[R] | Beijing K1 | 94–32 | Yes [37] | − |
12–17975 | T389G | Val130Gly | MDR+[R] | Beijing V+/CHIN+ | 9375–32 | A | |
12–16180 | T412C | Cys138Arg | XDR+[R] | Beijing V+/CHIN+ | 100–32 | A | |
12–17047 | A422C | Gln141Pro | MDR+[R] | Beijing V+/CHIN+ | 100–135 | A | |
12–18057 12–17993 12–16295 12–15251 12–18055 12–18893 12–19128 | A422C | Gln141Pro | MDR+[R] | Beijing V+/CHIN+ | 100–32 | See above | See above |
12–17736 | A422C | Gln141Pro | MDR+[R] | Beijing V+/CHIN+ | 9368–32 | See above | See above |
12–16850 | A422C | Gln141Pro | MDR+[R] | Beijing V+/CHIN+ | other | See above | See above |
12–14180 | C425T | Thr142Met | MDR+[R] | Beijing K1 | 94–32 | A | |
12–18166 | T448:G | Insertion → frameshift | MDR+[R] | Beijing V+/CHIN+ | 100–32 | No | − |
13–2219 | wildtype | − | MDR+[S] | LAM | 8013–52 | − | − |
12–17795 | wildtype | − | mono-INH+[S] | LAM | 843–52 | − | − |
12–16706 | wildtype | − | pan-susceptible + [S] | Beijing K1 | 94–32 | − | − |
12–16496 12–15156 | wildtype | − | mono-INH+[S] | Beijing V+/CHIN+ | 94–32 | − | − |
12–16505 | wildtype | − | mono-INH+[S] | Beijing V+/CHIN+ | 407–32 | − | − |
12–17231 | wildtype | − | MDR+[S] | Beijing V+/CHIN+ | 94–32 | − | − |
12–15460 | wildtype | − | pan-susceptible + [S] | Beijing V+/CHIN+ | 94–32 | − | − |
13–56 | wildtype | − | MDR-TB+[S] | Beijing V+/CHIN+ | 100–32 | − | − |
12–18360 | wildtype | − | MDR-TB+[S] | Beijing V- | 14852–32 | − | − |
12–19069 | wildtype | − | MDR-TB+[S] | Euro-American | 163–15 | − | − |
12–18493 | wildtype | − | MDR-TB+[S] | Beijing K1 | 94–32 | − | − |
12–15155 | wildtype | − | INHR+[S] | Euro-American | ?-15 | − | − |
12–13700 | wildtype | − | INHR+[S] | Haarlem | ?-31 | − | − |
13–2072 | wildtype | − | INHR+[S] | Euro-American | 12411–15 | − | − |
13–421 | wildtype | − | INHR+[S] | Haarlem | 7361–31 | − | − |
12–18490 | wildtype | − | INHR+[S] | Euro-American | 768–26 | − | − |
13–172 | wildtype | − | SR+[S] | Beijing V+/CHIN+ | other | − | − |
12–15239 | wildtype | − | pan-susceptible + [S] | X | ?-15 | − | − |
12–15737 | wildtype | − | pan-susceptible + [S] | CAS | 1059–25 | − | − |
12–16196 | wildtype | − | pan-susceptible + [S] | Beijing SA−/CHIN- | 785–32 | − | − |
12–18942 | wildtype | − | pan-susceptible + [S] | Beijing K1 | other | − | − |
13–1 | wildtype | − | pan-susceptible + [S] | Beijing V+/CHIN+ | other | − | − |