Microbiota-dependent metabolite and cardiovascular disease marker trimethylamine-N-oxide (TMAO) is associated with monocyte activation but not platelet function in untreated HIV infection

Table 1 Clinical characteristics of the study cohort

	Untreated (n = 50)	ART-Treated (n = 49)	P value
Age, years	41 (33–46)	43 (36–48)	0.249
Sex	90% (45) Male	88% (43) Male	0.722
Etnicity	90% (45) Caucasian	86% (42) Caucasian	0.514
Transmission of HIV	82% (41) MSM	74% (36) MSM	0.618
Current smoker	42% (21)	41% (20)	0.869
HIV-RNA, (copies/mL)	23,026 (5517–90,321)	19 (19–20)	< 0.001
Current CD4⁺ T-cell count, (cells/μL)	560 (415–795)	610 (480–875)	0.363
Duration of HIV^a (months)	28 (8–75)	73 (36–151)	0.009

Summary of clinical and demographic characteristics of the study population previously published in [31]. from Continuous data are presented as medians and (interquartile ranges) and categorical data as percentages and (total numbers). Untreated and treated individuals were compared by Mann-Whitney U test
^aDuration since 1^st positive HIV-1 test
cART antiretroviral therapy, MSM Men who have sex with men

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