Inclusion criteria | Exclusion criteria |
---|---|
Is willing and able to give informed consent to participate in the trial treatment and follow-up (signed or witnessed consent if the patient is illiterate) | Is HIV positive |
Is aged of 18–65 years old | Is concomitant with mental disorders |
Is previously untreated or treated less than 1 month with anti-TB drugs | Is concomitant with diabetes while mellitus blood glucose out of control |
Has 2 positive sputum smear results for mycobacterium TB at screening | Is pregnant or breastfeeding |
Has a chest X-ray abnormality compatible with a diagnosis of PTB | Has a prolonged QTcFa (>480 ms) |
Is not pregnant for female patient at bearing age and willing to use effective contraception during study period | Is currently participate in another trial of a medicinal product |
Has CrClb > 30 ml/ min, HBc > 7.0 g/dL and PLTd > 50 × 109/L at screening | Is concomitant with severe cardiovascular, hepatic, renal, nervous system, hematopoietic system injury and other diseases, or concomitant with neoplastic diseases |
Has ALTe and TBILf less than 2 times the upper limit of normal at screening | Has extensive lesion in the lung concomitant with respiratory insufficiency |
Has known allergy to any of the anti-TB drugs in the trial | |
Is taking any medications contraindicated with the medicines in any trial regimen of the study |