|  | SMA (Hb < 6.0 g/dL) | SMA (Hb < 5.0 g/dL) |
|---|
IL-23R haplotypes
| OR | 95% CI |
P-value | OR | 95% CI |
P-value |
|---|
 GC, (n = 342) | 0.49 | 0.18–1.33 | 0.161 | 0.34 | 0.13–1.17 | 0.107 |
 GT, (n = 17) | 1.04 | 0.33–3.31 | 0.949 | 1.92 | 0.52–7.06 | 0.328 |
 TC, (n = 67) | 0.97 | 0.52–1.81 | 0.923 | 1.02 | 0.49–2.15 | 0.955 |
 TT, (n = 56) | 1.12 | 1.07–4.19 |
0.030
| 2.50 | 1.19–5.29 |
0.016
|
- Haplotypes and SMA
- Children with P. falciparum malaria (n = 369) were grouped based on the modified definition of SMA (i.e., Hb < 6.0 g/dL, with any density parasitemia). Odds ratios (OR) and 95% confidence intervals (CI) were determined using logistic regression model controlling for age, sex, co-infections (HIV-1 and bacteremia) sickle cell trait (HbAS), G6PD deficiency, and alpha-thalassemia. The reference groups in the regression analysis were non-carriers of the respective haplotypes
- Values in bold are significant p-values at a cut-off of p < 0.05
