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Table 3 Association between IL-23R rs1884444 G/T and IL-23R rs7530511 C/T genotypes and SMA

From: Haplotype of non-synonymous mutations within IL-23R is associated with susceptibility to severe malaria anemia in a P. falciparum holoendemic transmission area of Kenya

 

SMA (Hb < 6.0 g/dL

SMA (Hb < 5.0 g/dL

Genotypes

OR

95% Cl

P value

OR

95% CI

P value

IL-23R rs1884444 G/T

IL-23R rs1884444 G/T

GG, (n = 253)

Ref

-

-

Ref

-

-

GT, (n = 100)

1.34

0.78–2.31

0.304

3.69

0.89–5.13

0.174

TT, (n = 16)

2.02

0.53–7.74

0.286

1.39

0.73–2.64

0.316

IL-23R rs7530511 C/T

IL-23R rs7530511 C/T

CC, (n = 303)

Ref

-

-

Ref

-

-

CT, (n = 54)

2.60

0.59–11.86

0.202

2.02

0.43–9.42

0.372

TT, (n = 12)

1.66

0.84–3.27

0.142

2.49

0.76–5.37

0.102

  1. Children (n = 369) with P. falciparum malaria were categorized on the basis of presence or absence of severe malarial anemia SMA (defined as Hb < 6.0 g/dL, with any density parasitemia). Odds ratios (OR) and 95% confidence intervals (CI) were determined using logistic regression, controlling for age, sex, co-infections (HIV-1 status and bacteremia), sickle cell trait (HbAS), G6PD deficiency, and alpha-thalassemia. The reference groups in the logistic regression analysis were the homozygous wild-type genotypes
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BMC Infectious Diseases

ISSN: 1471-2334

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