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Table 5 Association of variables with subsequent hemodialysis requirement in patients with severe malaria

From: Cell-free hemoglobin mediated oxidative stress is associated with acute kidney injury and renal replacement therapy in severe falciparum malaria: an observational study

 

Univariable analysis

Multivariable F2-IsoP model

Multivariable IsoF model

Variable

OR (95% CI)a

P

OR (95% CI)a

P

OR (95% CI)a

P

CFH

1.01 (0.99 to 1.03)

0.063

---

---

1.06 (0.98 to 1.14)

0.156

Log F2-IsoP#

3.45 (1.30 to 9.16)

0.013

7.37 (1.86 to 29.23)

0.005

---

---

Log IsoF

3.48 (1.62 to 7.49)

0.001

---

---

5.50 (1.76 to 17.24)

0.003

LogPfHRP2

1.92 (1.27 to 2.91)

0.002

---

---

---

---

LogRCD at SS 1.69 Pa

0.29 (0.08 to 1.09)

0.066

---

---

---

---

LogRCD at SS 9.49 Pa

0.10 (0.01 to 0.75)

0.025

0.057 (0.002 to 1.33)

0.075

0.031 (0.001 to 1.44)

0.076

Age

1.00 (0.97 to 1.03)

0.940

---

---

---

---

SBP

1.02 (0.99 to 1.04)

0.260

  

---

---

Number of severity criteria

1.90 (1.38 to 2.62)

<0.001

---

---

---

---

GCS

0.95 (0.85 to 1.07)

0.393

---

---

---

---

LogLactate

1.22 (0.64 to 2.30)

0.548

---

---

---

---

  1. aOdds ratio (OR) with 95% confidence intervals (CIs) showing the hemodialysis requirement predicted by a 1-U change in the independent (predictor) variables. A backward stepwise multivariable model included all variables in univariable analyses which were removed on the basis of P ≥ 0.05. Abbreviations: CFH cell free hemoglobin, F 2 -IsoP plasma F2-isoprostanes, IsoF plasma isofurans, PfHRP2 P. falciparum histidine rich protein 2, RCD red cell deformability at shear stress 1.69 and 9.49 Pa, SBP systolic blood pressure, GCS Glasgow Coma Score. # Plasma IsoFs collinear with plasma F2- IsoPs. P-values in italics denote statistical significance
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BMC Infectious Diseases

ISSN: 1471-2334

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