White British |  | Age at EBV infection | Unadjusted OR (95% CI) | Unadjusted OR (95% CI) n = 361 | Adjusted OR (95% CI) n = 361 | ||
by 12 mths | 12–24 mths | uninfected at 24 mths | |||||
All children, n = 391 | 28 (7%) | 71 (18%) | 292 (75%) |  |  |  | |
Birth order (391) | 1 | 10 (5%) | 33 (18%) | 141 (77%) | 1.0 | - | - |
2 | 10 (8%) | 18 (14%) | 100 (78%) | 0.95 (0.56–1.63) | - | - | |
3+ | 8 (10%) | 20 (25%) | 51 (65%) | 1.80 (1.02–3.17) | - | - | |
Total household members at 12 m (389) | median IQR, range | 4 3–4.5, 2–8 | 4 3–5, 2–7 | 4 3–4, 2–8 | 1.20 (0.97–1.47) | 1.19 (0.97–1.47) | 0.91 (0.63–1.33) |
No. of children (<16y) in household at 12 m (369) | median IQR, range | 2 1–3, 1–6 | 1 1–2, 1–5 | 2 1–2, 1–4 | 1.36 (1.07–1.74) | 1.34 (1.05–1.71) | 1.53 (0.96–2.42) |
Duration of breastfeeding (390) | never | 12 (12%) | 20 (19%) | 70 (69%) | 1.0 | 1.0 | 1.0 |
<=4 weeks | 8 (8%) | 20 (20%) | 71 (72%) | 0.83 (0.46–1.51) | 0.78 (0.42–1.47) | 0.96 (0.48–1.89) | |
1–6 months | 7 (7%) | 16 (17%) | 72 (76%) | 0.68 (0.36–1.27) | 0.62 (0.33–1.18) | 0.88 (0.43–1.78) | |
6–12 months | 1 (2%) | 11 (17%) | 53 (81%) | 0.46 (0.22–0.97) | 0.44 (0.21–0.94) | 0.74 (0.31–1.76) | |
>12 months | 0 | 4 (14%) | 25 (86%) | 0.32 (0.10–1.00) | 0.31 (0.10–0.96) | 0.58 (0.17–2.00) | |
Bedroom sharing in first year (389) | no | 15 (7%) | 36 (16%) | 169 (77%) | 1.0 | Â | - |
yes | 13 (8%) | 35 (21%) | 121 (72%) | 1.30 (0.82–2.04) |  | - | |
Bedroom sharing in second year (391) | No | 14 (6%) | 43 (17%) | 191 (77%) | 1.0 | 1.0 | 1.0 |
yes | 14 (10%) | 28 (19%) | 101 (71%) | 1.43 (0.90–2.27) | 1.59 (0.99–2.57) | 1.21 (0.71–2.07) | |
Informal child care from 12Â m to 24Â m visit: total hours (384) | No childcare | 12 (10%) | 21 (17%) | 92 (74%) | 1.0 | 1.0 | 1.0 |
<1165 total hours | 3 (7%) | 13 (29%) | 28 (64%) | 1.45 (0.71–2.96) | 1.31 (0.62–2.78) | 2.48 (1.04–5.92) | |
> = 1165 total hours | 4 (10%) | 6 (15%) | 31 (75%) | 0.91 (0.40–2.05) | 0.89 (0.39–2.02) | 1.54 (0.61–3.86) | |
No informal (only formal) | 3 (3%) | 17 (16%) | 87 (81%) | 0.61 (0.33–1.13) | 0.56 (0.30–1.05) | 0.87 (0.43–1.75) | |
No 24 m childcare, only 12 m | 6 (9%) | 12 (18%) | 49 (73%) | 1.01 (0.52–1.97) | 1.00 (0.51–1.99) | 1.05 (0.50–2.20) | |
Mother and baby activities in first year (389) | Rarely | 23 (11%) | 44 (21%) | 142 (68%) | 1.0 | 1.0 | 1.0 |
At least once a month | 5 (3%) | 27 (15%) | 148 (82%) | 0.44 (0.27–0.71) | 0.44 (0.27–0.71) | 0.53 (0.31–0.90) | |
Mother and baby activities in second year (389) | Rarely | 13 (8%) | 34 (22%) | 111 (70%) | 1.0 | Â | - |
At least once a month | 15 (6%) | 37 (16%) | 179 (78%) | 0.69 (0.44–1.09) |  | - | |
Maternal age at recruitment (391) | Mean, SD, range | 26.6, 5.34 18–35 | 28.1, 5.83 16–41 | 29.4, 5.99 15–43 | 0.95 (0.91–0.99) | 0.95 (0.91–0.99) | 0.96 (0.91–1.01) |
Maternal education (391) | 5 GCSE equivalent or less | 18 (11%) | 32 (20%) | 107 (68%) | 1.0 | 1.0 | 1.0 |
A level equiv & higher | 9 (5%) | 32 (17%) | 149 (78%) | 0.56 (0.35–0.91) | 0.55 (0.34–0.89) | 0.86 (0.47–1.60) | |
other/DK/foreign unknown | 1 (2%) | 7 (16%) | 36 (82%) | 0.45 (0.20–1.03) | 0.36 (0.14–0.91) | 0.46 (0.17–1.25) | |
Home ownership (391) | Yes | 12 (5%) | 41 (17%) | 192 (78%) | 1.0 | 1.0 | 1.0 |
No | 16 (11%) | 30 (21%) | 100 (68%) | 1.73 (1.09–2.73) | 1.65 (1.03–2.64) | 0.94 (0.50–1.74) | |
Age 24 m blood sample taken (mths) (391) | 23.59–24.99 | 9 (11%) | 11 (13%) | 64 (76%) | 1.0 | 1.0 | 1.0 |
25–26.99 | 18 (8%) | 36 (16%) | 174 (76%) | 0.96 (0.53–1.72) | 1.01 (0.55–1.87) | 1.04 (0.54–1.99) | |
27–32.89 | 1 (1%) | 24 (30%) | 54 (68%) | 1.26 (0.64–2.48) | 1.26 (0.62–2.57) | 1.21 (0.57–2.57) | |
Pakistani |  | by 12 mths | 12–24 mths | uninfected at 24 mths | Unadjusted OR (95% CI) | Unadjusted OR (95% CI) n = 453 | Adjusted OR (95% CI) n = 453 |
All children, n = 472 | 101 (21%) | 140 (30%) | 231 (49%) |  | |||
Birth order (472) | 1 | 26 (21%) | 38 (30%) | 62 (49%) | 1.0 | Â | - |
2 | 24 (22%) | 31 (29%) | 52 (49%) | 1.05 (0.65–1.71) |  | - | |
3+ | 51 (21%) | 71 (30%) | 117 (49%) | 1.02 (0.68–1.53) |  | - | |
Total household members at 12 m (468) | median IQR, range | 6 5–7, 3–13 | 6 4–7, 3–15 | 5 4–7, 2–15 | 1.07 (1.00–1.16) | 1.07 (0.99–1.15) | 1.07 (0.98–1.17) |
No. of children (<16y) in household at 12 m (456) | median IQR, range | 3 2–4, 1–8 | 3 2–4, 1–7 | 3 2–4, 1–7 | 1.08 (0.95–1.23) | 1.08 (0.94–1.22) | 1.03 (0.87–1.20) |
Duration of breastfeeding (468) | never | 21 (25%) | 21 (25%) | 42 (50%) | 1.0 | 1.0 | 1.0 |
<=4 weeks | 25 (27%) | 29 (32%) | 37 (41%) | 1.34 (0.77–2.35) | 1.53 (0.87–2.70) | 1.65 (0.92–2.96) | |
1–6 months | 24 (20%) | 36 (30%) | 61 (50%) | 0.90 (0.53–1.53) | 0.87 (0.51–1.49) | 0.82 (0.48–1.43) | |
6–12 months | 17 (17%) | 32 (31%) | 53 (52%) | 0.82 (0.47–1.41) | 0.82 (0.47–1.43) | 0.73 (0.41–1.29) | |
>12 months | 14 (20%) | 19 (27%) | 37 (53%) | 0.84 (0.46–1.54) | 0.87 (0.47–1.61) | 0.88 (0.47–1.63) | |
Bedroom sharing in first year (468) | no | 2 (6%) | 10 (32%) | 19 (61%) | 1.0 | 1.0 | 1.0 |
yes | 99 (23%) | 128 (29%) | 210 (48%) | 1.94 (0.95–3.96) | 1.95 (0.95–3.99) | 2.06 (0.99–4.28) | |
Bedroom sharing in second year (472) | no | 4 (17%) | 5 (21%) | 15 (62%) | 1.0 | Â | - |
yes | 97 (22%) | 135 (30%) | 216 (48%) | 1.70 (0.74–3.90) |  | - | |
Bed sharing in second year (471) | No | 55 (21%) | 70 (26%) | 142 (53%) | 1.0 | Â | - |
yes | 46 (22%) | 69 (34%) | 89 (44%) | 1.35 (0.96–1.90) |  | - | |
Any regular child care arrangement up to 24Â m visit (472) | no | 87 (23%) | 106 (28%) | 187 (49%) | 1.0 | 1.0 | 1.0 |
yes | 14 (15%) | 34 (37%) | 44 (48%) | 0.91 (0.60–1.38) | 0.89 (0.58–1.37) | 0.97 (0.62–1.53) | |
Mother and baby activities in first year (468) | Rarely | 88 (22%) | 124 (31%) | 193 (48%) | 1.0 | 1.0 | 1.0 |
At least once a month | 13 (21%) | 14 (22%) | 36 (57%) | 0.74 (0.44–1.25) | 0.67 (0.40–1.15) | 0.61 (0.35–1.06) | |
Mother and baby activities in second year (472) | Rarely | 58 (23%) | 78 (31%) | 117 (46%) | 1.0 | Â | - |
At least once a month | 43 (20%) | 62 (28%) | 114 (52%) | 0.80 (0.57–1.13) |  | - | |
Age 24 m blood sample taken (mths) (472) | 23.59–24.99 | 20 (22%) | 22 (24%) | 49 (54%) | 1.0 | 1.0 | 1.0 |
25–26.99 | 46 (19%) | 70 (29%) | 124 (52%) | 1.02 (0.64–1.62) | 0.98 (0.61–1.57) | 1.10 (0.67–1.80) | |
27–32.89 | 35 (25%) | 48 (34%) | 58 (41%) | 1.50 (0.91–2.47) | 1.47 (0.88–2.46) | 1.78 (1.05–3.04) |